Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer  

作　　者：Zhi-Fang Jia Dong-Hui Cao Yan-Hua Wu Mei-Shan Jin Yu-Chen Pan Xue-Yuan Cao Jing Jiang 

机构地区：[1]Division of Clinical Research,the First Hospital of Jilin University,Changchun 130021,Jilin Province,China [2]Division of Pathology,the First Hospital of Jilin University,Changchun 130021,Jilin Province,China [3]Department of Gastrointestinal Surgery,the First Hospital of Jilin University,Changchun 130021,Jilin Province,China

出　　处：《World Journal of Gastroenterology》2019年第8期1012-1023,共12页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,No.81703293,81673145,and No.81373084;the Research Program of the Education Department of Jilin Province,No.2016487;the Scientific and Technological Development Program of Jilin Province,No.20180414055GH

摘　　要：BACKGROUND The lethal-7(let-7)family members and their targets are involved in the development and progression of tumors.Let-7-related polymorphisms have been reported to be associated with tumorigenesis and prognosis.In gastric cancer,however,the related studies are limited.AIM To investigate the role of let-7-related microRNA polymorphisms in the tumorigenesis and prognosis of gastric cancer in a Chinese population.METHODS A total of 898 gastric cancer patients and 992 tumor-free controls were recruited into this study from 2008 to 2013.Gastric cancer patients were followed periodically.Ten single nucleotide polymorphisms(SNPs)in the let-7 gene region or their target mRNAs were genotyped using the MassARRAY system and their associations with the risk for or overall survival of gastric cancer were analyzed.RESULTS All the ten SNPs were in Hardy-Weinberg equilibrium.The C allele of the rs3811463 polymorphism in the 3’-untranslated region(UTR)of LIN28A was associated with a lower risk of gastric cancer[odds ratio(OR)=0.74,95%confidence interval(CI):0.61-0.88,P=0.001]after adjustment for age and Helicobacter pylori status.Seven hundred and thirty-five gastric cancer patients who had undergone radical tumorectomy were included in the survival analysis and their 5-year survival rate was 53.9%(95%CI:50.1%-57.6%).The rs10889677 in the 3’-UTR of IL23R was corresponded to the prognosis of gastric cancer in a dose-response manner,in which the death risk increased by 25%[hazard ratio(HR)=1.25,95%CI:1.04-1.45,P=0.011]with each increase in the number of C alleles after controlling for other potential clinicopathological parameters.CONCLUSION The let-7-related polymorphism rs3811463 in LIN28A is associated with the susceptibility to gastric cancer and the let-7-related polymorphism rs10889677 in IL23R is associated with the prognosis of gastric cancer.BACKGROUND The lethal-7(let-7) family members and their targets are involved in the development and progression of tumors. Let-7-related polymorphisms have been reported to be associated with tumorigenesis and prognosis. In gastric cancer,however, the related studies are limited.AIM To investigate the role of let-7-related micro RNA polymorphisms in the tumorigenesis and prognosis of gastric cancer in a Chinese population.METHODS A total of 898 gastric cancer patients and 992 tumor-free controls were recruited into this study from 2008 to 2013. Gastric cancer patients were followed periodically. Ten single nucleotide polymorphisms(SNPs) in the let-7 gene region or their target m RNAs were genotyped using the Mass ARRAY system and their associations with the risk for or overall survival of gastric cancer were analyzed.RESULTS All the ten SNPs were in Hardy-Weinberg equilibrium. The C allele of the rs3811463 polymorphism in the 3’-untranslated region(UTR) of LIN28 A was associated with a lower risk of gastric cancer [odds ratio(OR) = 0.74, 95%confidence interval(CI): 0.61-0.88, P = 0.001] after adjustment for age and Helicobacter pylori status. Seven hundred and thirty-five gastric cancer patients who had undergone radical tumorectomy were included in the survival analysis and their 5-year survival rate was 53.9%(95%CI: 50.1%-57.6%). The rs10889677 in the 3’-UTR of IL23 R was corresponded to the prognosis of gastric cancer in a dose-response manner, in which the death risk increased by 25% [hazard ratio(HR) = 1.25, 95%CI: 1.04-1.45, P = 0.011] with each increase in the number of C alleles after controlling for other potential clinicopathological parameters.CONCLUSION The let-7-related polymorphism rs3811463 in LIN28 A is associated with the susceptibility to gastric cancer and the let-7-related polymorphism rs10889677 in IL23 R is associated with the prognosis of gastric cancer.

关 键 词：GASTRIC cancer Risk SUSCEPTIBILITY PROGNOSIS POLYMORPHISM Lethal-7 LIN28A IL23R 

分 类 号：R[医药卫生]