人类朊蛋白病研究进展及临床诊治展望  

Human Prion Disease research progress and clinical diagnosis and treatment prospect

作　　者：于松 吕姣[2] Yu Song;Lv Jiao(Department of Neurology, Northeast International Hospital Psychological clinic, Shenyang, Liaoning, 110000, China;The People' s Hospital of Liaoning province, Shenyang, Liaoning, 110000, China)

机构地区：[1]中一东北国际医院心理门诊,辽宁沈阳110000 [2]辽宁省人民医院神经内科,辽宁沈阳110000

出　　处：《当代医学》2019年第8期185-186,共2页Contemporary Medicine

摘　　要：人类朊蛋白病属于神经变性构象病的一种,它是由机体内正常的朊蛋白在机体内某些因素的作用下改变构象后所引起的疾病,同时被临床证实了具有一定的传染性。本综述探讨朊蛋白的细胞内生物合成和结构,它的神经生理功能,可能的致病机制,目前人类朊蛋白病的临床检测及诊治思路,效果以及展望。Human Prion Disease is a kind of neurodegenerative conformation disease. It is a disease caused by the changed conformation of the normal Prion Protein in the body. It has been proved to be contagious clinically. This review discusses the intracellular biosynthesis and structure of the Prion Protein, its neurophysiological functions, possible pathogenicity mechanism, the clinical detection, diagnosis and treatment of Human Prion Disease for now, and its effect and prospect.

关 键 词：朊蛋白 神经生理功能 致病机制 研究进展 朊蛋白病 

分 类 号：R742.9[医药卫生—神经病学与精神病学]