The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models  

作　　者：Shu-ran Gong Lin-lin Bao 

机构地区：[1]Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Key Laboratory for Animal Models of Emerging and Reemerging Infectious

出　　处：《Animal Models and Experimental Medicine》2018年第2期125-133,共9页动物模型与实验医学（英文）

基　　金：National Key Research and Development Project of China,Grant/Award Number:2016YFD0500304;CAMS Innovation Fund for Medical Sciences,Grant/Award Number:NO.2016-I2M-1-014\2016-12M-006;the Chinese National Major S&T Project,Grant/Award Number:NO.2017ZX10304402-001-003

摘　　要：In humans, infection with the coronavirus, especially the severe acute respiratory syndrome coronavirus(SARS-CoV) and the emerging Middle East respiratory syndrome coronavirus(MERS-CoV), induces acute respiratory failure, resulting in high mortality. Irregular coronavirus related epidemics indicate that the evolutionary origins of these two pathogens need to be identified urgently and there are still questions related to suitable laboratory animal models. Thus, in this review we aim to highlight key discoveries concerning the animal origin of the virus and summarize and compare current animal models.In humans, infection with the coronavirus, especially the severe acute respiratory syndrome coronavirus(SARS-CoV) and the emerging Middle East respiratory syndrome coronavirus(MERS-CoV), induces acute respiratory failure, resulting in high mortality. Irregular coronavirus related epidemics indicate that the evolutionary origins of these two pathogens need to be identified urgently and there are still questions related to suitable laboratory animal models. Thus, in this review we aim to highlight key discoveries concerning the animal origin of the virus and summarize and compare current animal models.

关 键 词：animal models CORONAVIRUSES RESERVOIRS the Middle East RESPIRATORY syndrome(canonical form) the severe acute RESPIRATORY SYNDROME 

分 类 号：R[医药卫生]