急性脑梗死感染对抗氧化能力与血小板参数的影响  

Effect of infection on the anti-oxidative capacity and platelet parameter in acute cerebral infarction patients

作　　者：刘云红[1] 孙明洁[1] 张佑健 马冰[1] LIU Yunhong;SUN Hongjie;ZHANG Youjian;MA Bing(Henan Province People's Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院,河南郑州450003

出　　处：《中国实用神经疾病杂志》2019年第2期144-148,共5页Chinese Journal of Practical Nervous Diseases

基　　金：2017年度河南省医学科技攻关计划项目(编号:201702214)

摘　　要：目的探讨急性脑梗死合并感染患者抗氧化能力与血小板参数的变化。方法选取2016-01—2017-12河南省人民医院收治的急性脑梗死合并感染患者67例为研究组,同时选取同期入院治疗的脑梗死未合并感染患者70例为对照组,分别检测2组抗氧化能力指标和血小板参数,分析急性脑梗死感染对抗氧化能力和血小板参数的影响。另将研究组按照不同感染程度分组,分析急性脑梗死不同感染程度患者的抗氧化能力指标和血小板参数变化。结果研究组总抗氧化能力(TAC)、过氧化氢酶(CAT)、超氧化物岐化酶(SOD)等抗氧化能力指标与血小板平均容积(MPV)、血小板体积分布宽度(PDW)、血小板计数(PLT)及大型血小板比率(P-LCR)等血小板参数均明显差于对照组,差异有统计学意义(P<0.05);研究组重度感染患者抗氧化能力指标和血小板参数均明显差于轻度感染者,差异有统计学意义(P<0.05)。结论脑梗死合并感染患者抗氧化能力指标和血小板参数明显较无感染患者较差,且随着感染程度的加重越来越差,治疗过程中应给予充分重视。Objective To discuss the variations of the anti-oxidative capacity and platelet parameter in co-infected patients with the acute cerebral infarction(ACI).Methods Sixty-seven co-infected patients with ACI and seventy patients with ACI without infection admitted to our hospital from January 2016 to December 2017 were served as a research group and a control group,respectively.The total anti-oxidative capacity(TAC)and platelet parameter of both groups were measured.The effect of ACI and infection level on TAC and platelet parameter were studied.Results There is a significant difference about TAC,CAT,SOD,MPV,PDW,PLT and P-LCR in the research group and control group(P<0.05).The anti-oxidative capacity and platelet parameter in the severe infection were lower than the mild infection(P<0.05).Conclusion The co-infected patients with ACI decreased the anti-oxidative capacity and platelet parameter,and the more severe infection,the worse.More attention should be given to in the treatment of the co-infected patients with ACI.

关 键 词：急性脑梗死 感染 抗氧化能力 血小板参数 过氧化氢酶 

分 类 号：R743.33[医药卫生—神经病学与精神病学]