Release and uptake mechanisms of vesicular Ca^2+stores  

作　　者：Junsheng Yang Zhuangzhuang Zhao Mingxue Gu Xinghua Feng Haoxing Xu 

机构地区：[1]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China [2]The Department of Molecular,Cellular,and Developmental Biology,University of Michigan,Ann Arbor,Ml 48109,USA

出　　处：《Protein & Cell》2019年第1期8-19,共12页蛋白质与细胞（英文版）

摘　　要：Cells utilize calcium ions(Ca^2+)to signal almost all aspects of cellular life,ranging from cell proliferation to cell death,in a spatially and temporally regulated manner.A key aspect of this regulation is the compartmen-talization of Ca^2+in various cytoplasmic organelles that act as intracellular Ca^2+stores.Whereas Ca^2+release from the large-volume Ca^2+stores,such as the endoplasmic reticulum(ER)and Golgi apparatus,are preferred for signal transduction,Ca^2+release from the small-volume individual vesicular stores that are dispersed throughout the cell,such as lysosomes,may be more useful in local regulation,such as membrane fusion and individualized vesicular movements.Conceivably,these two types of Ca^2+stores may be established,maintained or refilled via distinct mechanisms.ER stores are refilled through sustained Ca^2+influx at ER-plasma membrane(PM)membrane contact sites(MCSs).In this review,we discuss the release and refilling mechanisms of intracellular small vesicular Ca^2+stores,with a special focus on lysosomes.Recent imaging studies of Ca2+release and organelle MCSs suggest that Ca^2+exchange may occur between two types of stores,such that the small stores acquire Ca^2+from the large stores via ER-vesicle MCSs.Hence vesicular stores like lysosomes may be viewed as secondary Ca^2+stores in the cell.

关 键 词：Ca^2+stores LYSOSOMES vesicles REFILLING ORGANELLE membrane contact sites(MCSs) 

分 类 号：Q[生物学]