Analysis of the results of Treponema Pallidum DNA in serum and vaginal fluid of patients with latent syphilis before and after treatment  

作　　者：GAO Hong 高红(Dept Med Lab,Ningbo Women and Children 's Hosp)

机构地区：[1]Dept Med Lab,Ningbo Women and Children 's Hosp

出　　处：《China Medical Abstracts(Internal Medicine)》2018年第4期206-207,共2页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To investigate the infectivity of serum and vaginal fluid in early cases and late latent cases of syphilis.Methods From January 2015 to December 2015,sixty-eight female patients with latent syphilis were enrolled in the outpatient clinic of Ningbo Women and Children's Hospital,including 38 early cases and 30 late cases.Tolulized red unheated serum test(TRUST)was detected by using kits and Treponema Pallidum DNA(TP-DNA)was detected by polymerase chain reaction.TP-DNA levels in serum and vaginal fluid were compared before and after benzathine penicillin treatment in patients with early and late latent syphilis.Chi square test was performed for count data analysis.Results TRUST negative conversion cases in early latent syphilis after 3,6 and 12 months of treatment were 11(28.9%),16(42.1%)and 27(71.0%),respectively.TRUST negative conversion cases in late latent syphilis after 3,6 and 12 months of treatment were 6(20.0%),12(40.0%)and 14(46.7%),respectively.There were no statistical differences in TRUST negative conversion rates after 3 months and 6 months after treatment between early cases and late cases(X^2=0.716 and 0.031,respectively,both P>0.05),while those after 12 months of treatment between early cases and late cases were statistically different(X^2=4.164,P<0.05).The vaginal fluid TP-DNA positive cases in early syphilis before and after 3,6,and 12 months of treatment were 4(10.5%),0,1(2.63%)and 1(2.63%),respectively,with no statis-tical difference(X^2=6.247,P>0.05).The serum TP-DNA positive cases in early syphilis before and after 3,6,and 12 months of treatment were 18(47.3%),4(10.5%),5(13.2%)and 5(13.2%),respectively,with statistical difference(X^2=21.217,P<0.05).The vaginal fluid TP-DNA positive cases in late syphilis before and after 3,6,and 12 months of treatment were 2(6.7%),0,0 and 1(3.3%),respectively,with no statistical difference(X^2=3.761,P>0.05).The serum TP-DNA positive cases in late syphilis before and after 3,6,and 12 months of treatment were 8(26.7%),1(3.3%),1(3.3%)and 1(3.3%),respecti

关 键 词：INVESTIGATE the infectivity benzathine PENICILLIN 

分 类 号：R[医药卫生]