Antiviral immunity: a link to bile acids  

作　　者：Jing Wang Richard A. Flavell Hua-Bing Li 

机构地区：[1]Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China [2]Yale Center for ImmunoMetabolism, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China [3]Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8055, USA [4]Howard Hughes Medical Institute, Yale University, New Haven, CT 06520-8055, USA

出　　处：《Cell Research》2019年第3期177-178,共2页细胞研究（英文版）

基　　金：National Natural Science Foundation of China (91753141 to HBL).

摘　　要：A recent study in Cell Research by Hu et al. describes a novel function of intracellular bile acids (BAs), a class of cholesterolderived metabolites, which activate several key innate antiviral signaling components through the TGR5-p-arrestin- SRC pathway to potentiate antiviral immunity. This finding adds a new metabolic regulatory dimension of innate antiviral response and provides a new antiviral strategy by supplementing BAs.

关 键 词：ANTIVIRAL IMMUNITY BILE ACIDS 

分 类 号：Q[生物学]