食源性蛋白酶抑制剂结构与功能  

Structure and Function of Foodborne Protease Inhibitors

作　　者：张允萍 吴子健[1] 李丹阳 ZHANG Yun-ping;WU Zi-jian;LI Dan-yang(School of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin Key Laboratory of Food and Biotechnology,Tianjin 300134,China)

机构地区：[1]天津商业大学生物技术与食品科学学院天津市食品生物技术重点实验室,天津300134

出　　处：《食品研究与开发》2019年第10期198-205,共8页Food Research and Development

基　　金：国家自然科学基金(31271841);天津市应用基础与前沿技术研究计划(青年项目)(15JCQNJC12200);天津市应用基础与前沿技术研究计划(一般项目)(14JCYBJC30900);天津市高等学校创新团队项目(TD13-5088)

摘　　要：食源性蛋白酶抑制剂(foodborne protease inhibitors,FPI)来源广泛,且种类繁多,研究分析这些FPI的特异性结构与其生理功能之间的关系具有十分重要的意义。该文首先综述蛋白酶抑制剂的来源、分类和作用机理;另外详细说明3种FPI(包括:Bowman-Birk型、Kunitz型以及Kazal型蛋白酶抑制剂等)命名的由来和其在结构上的区别,这些种类的FPI不仅可调节控制生物机体的蛋白质水解过程,同时还具有诸如调节机体防御、抗肿瘤、抗炎、抗凝血、预防肥胖等生理作用。Foodborne protease inhibitors (FPI) can be found from a variety of resources, and can be divided into many groups;furthermore, it is of great significance to understand the relationship between their specific structures and physiological functions. The resource, the classification and the functional mechanism of FPIs were summarized;in addition, three kinds of FPIs, including Bowman-Birk type, Kunitz type and Kazal type FPI, were explicated in detail, which involved the explanation of their resources and structural difference;these mentioned FPIs of three kinds not only regulated the proteolysis process of the biological organism, also had physiological functions such as body defensive regulation, anti-tumor function, anti-inflammation function, anti-coagulation function, and prevention of obesity.

关 键 词：蛋白酶抑制剂 Bowman-Birk型 Kunitz型 Kazal型 结构 抑制活性 

分 类 号：TS201.2[轻工技术与工程—食品科学]