The combination of four cell-cycle regulators: a new direction for inducing adult cardiomyocyte proliferation  

作　　者：Yiyuan Yang Kai Zhang Linxi Chen Lanfang Li 

机构地区：[1]Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China

出　　处：《Acta Biochimica et Biophysica Sinica》2019年第4期452-454,共3页生物化学与生物物理学报（英文版）

基　　金：National Natural Science Foundation of China (No. 81670265);Hunan Provincial Natural Science Foundation (No. 2017JJ2227).

摘　　要：Cardiomyocytes, also known as myocardial fibers, are the muscle cells which form the heart tissue. Previous studies have indicated that fetal mammalian cardiomyocytes maintain the regeneration capacity, which promotes the fetal heart growth. Regardless of environment insults including nutrient deprivation, changes of blood flow, along with mechanical and volume loading [1], embryonic mammalian cardiac muscle cells are also related to robust proliferation response. Similarly, the hearts of 1-day-old neonatal mice could also be fully regenerated after surgical resection of the left ventricular apex or myocardial infarction (MI)[2]. Intriguingly, studies have also shown that certain fish, such as adult zebrafish, or urodele amphibians retain an observable capacity for regeneration [3].

关 键 词：INDUCING ADULT CARDIOMYOCYTE proliferation myocardial infarction(MI) regeneration capacity 

分 类 号：Q[生物学]