Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis  

作　　者：Lijun Yan Vladimir Majerciak Zhi-Ming Zheng Ke Lan 

机构地区：[1]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China [2]National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA

出　　处：《Virologica Sinica》2019年第2期135-161,共27页中国病毒学（英文版）

基　　金：supported by the National Key R&D Program of China (2016YFA0502100);the Natural Science Foundation for Distinguished Young Scholars (81425017);the National Institutes of Health awarded (7R01AI116442) to K.L;the Intramural Research Program of NCI/NIH (1ZIASC010357) to ZMZ

摘　　要：Kaposi’s sarcoma-associated herpesvirus(KSHV), also known as human herpesvirus-8(HHV-8), is etiologically linked to the development of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. These malignancies often occur in immunosuppressed individuals, making KSHV infection-associated diseases an increasing global health concern with persistence of the AIDS epidemic. KSHV exhibits biphasic life cycles between latent and lytic infection and extensive transcriptional and posttranscriptional regulation of gene expression. As a member of the herpesvirus family, KSHV has evolved many strategies to evade the host immune response, which help the virus establish a successful lifelong infection. In this review, we summarize the current research status on the biology of latent and lytic viral infection, the regulation of viral life cycles and the related pathogenesis.Kaposi’s sarcoma-associated herpesvirus(KSHV), also known as human herpesvirus-8(HHV-8), is etiologically linked to the development of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. These malignancies often occur in immunosuppressed individuals, making KSHV infection-associated diseases an increasing global health concern with persistence of the AIDS epidemic. KSHV exhibits biphasic life cycles between latent and lytic infection and extensive transcriptional and posttranscriptional regulation of gene expression. As a member of the herpesvirus family, KSHV has evolved many strategies to evade the host immune response, which help the virus establish a successful lifelong infection. In this review, we summarize the current research status on the biology of latent and lytic viral infection, the regulation of viral life cycles and the related pathogenesis.

关 键 词：Kaposi's sarcoma-associated HERPESVIRUS (KSHV) Human HERPESVIRUS 8 (HHV-8)- TRANSCRIPTION Posttranscriptonal regulation ORF57 

分 类 号：Q[生物学]