喷雾干燥法制备水溶性白藜芦醇/HP-β-CD微胶囊  

Preparation of water-soluble resveratrol/HP-β-CD microcapsule by spray drying method

作　　者：唐宏伟[1] 旷春桃[1] 向舒[1] 李湘洲[1] 杨婷 易祥光 TANG Hongsei;KUANG Chun-tao;XIANG Shu;LI Xiang-zhou;YANG Ting;YI Xiang-guang(College of Material Science and Engineering, Central South University of Forestry andTechnology , Changsha, Hunan 410004. China)

机构地区：[1]中南林业科技大学材料科学与工程学院

出　　处：《食品与机械》2019年第4期192-196,共5页Food and Machinery

基　　金：“十三五”国家重点研发计划(编号:2016YFD0600805-04)

摘　　要：利用羟丙基-β-环糊精(HP-β-CD)改善Res的水溶性,优化了喷雾干燥法制备Res/HP-β-CD微胶囊的工艺,采用UV、IR和SEM对Res/HP-β-CD微胶囊进行结构表征.结果表明,Res/HP-β-CD微胶囊的优化制备工艺为w Res︰w HP-β-CD 1︰5(g/g),搅拌温度30℃,进料流量2.1 mL/min,进风温度140℃,载药量15.18%,溶解度12.75 g/L.UV、IR和SEM结果表明,Res与HP-β-CD通过氢键、疏水作用力等作用力形成Res/HP-β-CD微胶囊,并且粒径减少,提高了Res的水溶性.Hydroxypropyl-β-cyclodextrin(HP-β-CD)was used to improve water solubility of Res.The preparation conditions of Res/HP-β-CD microcapsule by spray drying method were optimized,and Res/HP-β-CD microcapsule was confirmed by UV,IR and SEM.The results showed that optimum preparation conditions of Res/HP-β-CD microcapsule were mass ratio of Res to HP-β-CD for 1:5,stirring at 30 ℃,feed flow rate for 2.1 mL/min and inlet-air temperature for 140 ℃.The rate of drug-loading and the solubility of Res were 15.18% and12.75 g/L,respectively,under the optimum conditions.UV,IR and SEM tests of Res/HP-β-CD microcapsule demonstrated that the aqueous solubility of Res increased due to the microcapsule formation between Res and HP-β-CD by hydrogen bond and hydrophobic forces,and the decrease of particle size.

关 键 词：白藜芦醇 羟丙基-Β-环糊精 水溶性 微胶囊 喷雾干燥法 

分 类 号：TQ460.1[化学工程—制药化工]