口腔来源蛋白及多肽诱导牙釉质仿生矿化的研究进展  

Research Progress on Biomimetic Enamel Mineralization Induced by Proteins and Peptides from Oral Cavity

作　　者：胡蝶 张凌琳[1] HU Die;ZHANG Ling-lin(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Conservative Dentistry and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科

出　　处：《口腔医学研究》2019年第6期517-520,共4页Journal of Oral Science Research

基　　金：国家自然科学基金(编号:81470734)

摘　　要：牙釉质生物矿化过程中,成釉细胞分泌各种蛋白介导有序棱柱状羟磷灰石晶体的形成,最终形成高度复杂而有序的牙釉质结构。当牙釉质结构遭到破坏后,寻求可诱导釉质微结构再生的仿生修复材料和方法是目前牙体修复研究的一大难点和热点。利用口腔来源的蛋白及多肽人工诱导牙釉质矿化过程,以实现牙釉质结构再生的仿生矿化修复被认为是一种很有前景的治疗手段。本文就近年来口腔来源的蛋白及其多肽诱导牙釉质仿生矿化的相关研究作一综述。During enamel biomineralization,ameloblasts secrete proteins to mediate the hydroxyapatite crystallites to form the well-organized prism pattern.Finally,a highly complex and ordered enamel structure is formed.When the enamel is destructed,it is of great difficulties and high popularity to find biomimetic reparative materials or methods that can induce the regeneration of enamel microstructure at present.Among them,enamel biomimetic mineralization using proteins derived from oral environment and their derived peptides is a promising way to rebuild the enamel.In this paper,we review the advancement of enamel biomimetic mineralization induced by proteins and their derived peptides from oral cavity according to the latest reports in recent years.

关 键 词：牙釉质 蛋白 多肽 仿生矿化 

分 类 号：R781.2[医药卫生—口腔医学]