A different view on the pathophysiology of Parkinson’s disease:a descendent neurochemical hypothesis?  

作　　者：Burak Yulug Mehmet Ozansoy Seyda Cankaya 

机构地区：[1]Department of Neurology,Alanya Alaaddin Keykubat University,Antalya/Alanya,Turkey [2]Istanbul Medipol University,Restorative and Regenerative Medicine Center,Istanbul,Turkey [3]Department of Physiology,International School of Medicine,Istanbul Medipol University,Istanbul,Turkey

出　　处：《Neural Regeneration Research》2019年第10期1717-1718,共2页中国神经再生研究（英文版）

摘　　要：It has been already shown that Parkinson’s disease (PD) is characterized by a prominent degeneration in substantia nigra (SN) neurons. Growing evidence suggests that there is a latent period of PD associated with slight non-motor findings such as olfactory dysfunction (Dickson et al., 2018). However, the potential biomarker role of olfactory dysfunction in PD has been a topic of great interest in the last years (Raskin et al., 1990;Dickson et al., 2018). The classical hypothesis of Braak suggests that PD begins as a synucleinopathy in the lower brainstem or in the olfactory bulb (OB) that progresses rostrally to the SN and amygdala to cause parkinsonism at a later stage of the disease (Burke et al., 2008).

关 键 词：PARKINSON period CAUSE has NEU PD is 

分 类 号：R742.5[医药卫生—神经病学与精神病学]