Gait Assessment of Pain and Analgesics: Comparison of the DigiGait^(TM) and CatWalk^(TM） Gait Imaging Systems  

作　　者：Yu Xu Na-Xi Tian Qing-Yang Bai Qi Chen Xiao-Hong Sun Yun Wang 

机构地区：[1]Neuroscience Research Institute and Department of Neurobiology,School of Basic Medical Sciences,Key Laboratory for Neuroscience,Ministry of Education/National Health Commission,Peking University,Beijing 100083,China [2]PKU-IDG/McGovem Institute for Brain Research,Peking University,Beijing 100871,China [3]Department of Neurobiology,Capital Medical University,Beijing 100069,China

出　　处：《Neuroscience Bulletin》2019年第3期401-418,共18页神经科学通报（英文版）

基　　金：grants from the National Natural Science Foundation of China(31720103908 and31530028);the National Key Technology Support Program of the Ministry of Science and Technology of China(2017YFA0701300)

摘　　要：Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors.Recent studies have indicated the superiority of gait analysis over traditional evaluations(e.g., skin sensitivity and sciatic function index [SFI]) in detecting subtle improvements and deteriorations in animal models. Here,pain-related gait parameters, whose criteria include(1)alteration in pain models,(2) correlation with nociceptive threshold, and(3) normalization by analgesics, were identified in representative models of neuropathic pain(spared nerve injury: coordination data) and inflammatory pain(intraplantar complete Freund’s adjuvant: both coordination and intensity data) in the DigiGait^TM and CatWalk^TM systems. DigiGait^TM had advantages in fixed speed(controlled by treadmill) and dynamic SFI, while CatWalk^TM excelled in intrinsic velocity, intensity data,and high-quality 3 D images. Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research.Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors.Recent studies have indicated the superiority of gait analysis over traditional evaluations（e.g., skin sensitivity and sciatic function index [SFI]） in detecting subtle improvements and deteriorations in animal models. Here,pain-related gait parameters, whose criteria include（1）alteration in pain models,（2） correlation with nociceptive threshold, and（3） normalization by analgesics, were identified in representative models of neuropathic pain（spared nerve injury: coordination data） and inflammatory pain（intraplantar complete Freund’s adjuvant: both coordination and intensity data） in the DigiGaitTM and CatWalkTM systems. DigiGaitTM had advantages in fixed speed（controlled by treadmill） and dynamic SFI, while CatWalkTM excelled in intrinsic velocity, intensity data,and high-quality 3 D images. Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research.

关 键 词：Gait analysis DigiGait^(TM) CatWalk^(TM) Neuropathic pain Inflammatory pain ANALGESIC 

分 类 号：R[医药卫生]