氧化葡萄糖酸杆菌生物制造吡咯喹啉醌进展  

Research progress in production of pyrroloquinoline quinone by Gluconobacter oxydans

作　　者：胡鸿雨[1] 孙晓明 袁建锋 HU Hongyu;SUN Xiaoming;YUAN Jianfeng(Xingzhi College,Zhejiang Normal University,Lanxi 314100,China)

机构地区：[1]浙江师范大学行知学院

出　　处：《中国酿造》2019年第6期13-17,共5页China Brewing

基　　金：浙江省教育厅一般基金资助项目(KYZ04Y17068);浙江师范大学实验技术开发资助项目(SJ201824)

摘　　要：吡咯喹啉醌(PQQ)是继黄素核苷酸和吡啶核苷酸之后,在膜束缚的细菌脱氢酶中发现的第三种辅基,具有抗氧化、抗病毒和提高免疫力等多种生理功能,在食品、医药及农业等行业具有广泛的应用前景。该文综述了氧化葡萄糖酸杆菌(Gluconobacter oxydans)中PQQ的生理作用及生物合成的分子机制,表明了氧化葡萄糖酸杆菌作为出发菌株生产PQQ具有潜在优势,对今后工业化生产PQQ具有积极的指导意义。Pyrroloquinoline quinone (PQQ), a third prosthetic group, was found in membrane-bound bacterial dehydrogenase following riboflavin and pyridine nucleotide. It was wildly used in food, medicine and agriculture industry for its various physiological functions, such as antioxidant, anti-virus and immune function. In this article, the physiological role and molecular mechanism of biosynthesis of PQQ in Gluconobacter oxydans were reviewed. Results showed that G. oxydans had the potential advantages for PQQ production. Hence, it has positive guidance significance for the future PQQ industrial production.

关 键 词：吡咯喹啉醌 氧化葡萄糖酸杆菌 生物制造 

分 类 号：TQ92[轻工技术与工程—发酵工程]