Cyclosporine A-loaded drug delivery systems inhibit scar formation after glaucoma surgery in rabbits  

作　　者：Zhao-Xing Dai Xiao-Le Song Xiao-Bo Yu Jian-Guo Sun Xing-Huai Sun 

机构地区：[1]Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China [2]Department of Ear-Nose-Throat, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China [3]Research Center, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China [4]Key Laboratory of Myopia, NHFPC, and Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China [5]State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

出　　处：《Chinese Medical Journal》2019年第11期1381-1384,共4页中华医学杂志（英文版）

摘　　要：To the Editor:Glaucoma is the primary cause of irreversible blindness. Surgery is the main treatment option if intraocular pressure (IOP) cannot be controlled with medications. Local fibroblast proliferation and collagen deposition cause stenosis of drainage channels and scar formation in the filtration area, which are the main causes of unsuccessful antiglaucoma surgery. Application of mitomycin C during surgery is one of the most widely performed clinical interventions aimed at modifying the wound healing process. However, recent reports suggest that there is scope to further improve the outcomes of mitomycin C application in surgery.

关 键 词：GLAUCOMA INTRAOCULAR pressur MITOMYCIN C 

分 类 号：R[医药卫生]