Preparation and Spectroscopic of Vanadyl（Ⅱ） Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug  

作　　者：Enas Aljuhani Amnah M.A.Alsuhaibani A.M.El-Di damony N.Hassan Sameh Abo Taleb Moamen S.Refat 

机构地区：[1]Department of Chemistry,Faculty of Applied Science,Umm Al-Qura University,Makkah,P.O.9168 Zip Code 21955,Saudi Arabia [2]Nutrition and Food Sciences Dept.,Home Economic College,Princess Nourah Bint Abdulrahman University,Riyadh,Saudi Arabia [3]Department of Chemistry,Faculty of Science,Zagazig University,Egypt [4]Department of Chemistry,Faculty of Science,Port Said,Port Said University,Egypt [5]Chemistry Department,Faculty of Science,Taif University,P.O.Box 888,Al-Hawiah,Taif 21974,Saudi Arabia

出　　处：《光谱学与光谱分析》2019年第7期2316-2324,共9页Spectroscopy and Spectral Analysis

摘　　要：A new six intraperitoneal injection insulin-mimetic vanadyl(Ⅱ) compounds [(VD3^-1)(VO^+2)(AAn^-1)](where(n=1~6);AA1=isoleucine, AA2=threonine, AA3=proline, AA4=phenylalanine, AA5=lysine and AA6=glutamine) were synthesized by the chemical reactions between vitamin D3(VD3), VOSO4 and amino acids(AAn) with equal molar ratio 1∶1∶1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl(Ⅳ) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.A new six intraperitoneal injection insulin-mimetic vanadyl（Ⅱ） compounds [（VD■）(VO+2)(AA-1n)]（where（n=1～6）; AA1=isoleucine, AA2=threonine, AA3=proline, AA4=phenylalanine, AA5=lysine and AA6=glutamine） were synthesized by the chemical reactions between vitamin D3（VD3）, VOSO4 and amino acids（AAn） with equal molar ratio 1∶1∶1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl（Ⅳ） ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.

关 键 词：INSULIN alternative Diabetes DRUG VO^2+ ion VITAMIN D3 Amino acid SPECTROSCOPIC 

分 类 号：R458.3[医药卫生—治疗学]