Interaction between cannabinoid and nucleotide systems as a new mechanism of signaling in retinal cell death  

作　　者：Hércules R. Freitas Ricardo A. M. Reis Ana L. M. Ventura Guilherme R. Franca 

机构地区：[1]Laboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil [2]School of Health Sciences, Centro Universitário IBMR, Rio de Janeiro, RJ, Brazil [3]Laboratory of Neurochemistry, Institute of Biology, Universidade Federal Fluminense, Niterói, RJ, Brazil [4]Biomedical Institute, Departament of Physiological Sciences/ Pharmacology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

出　　处：《Neural Regeneration Research》2019年第12期2093-2094,共2页中国神经再生研究（英文版）

基　　金：supported by Coordenaqao de Aperfeigoamento dePessoal de Nivel Superior (CAPES),No.oo1 and PROCAD-2013(both to RAM);Conselho Nacional de Desenvolvimento Cientificoe Tecnologico (CNPq),No.303018/2016-0 (to ALMV);FundacaoCarlos Chagas Filho de Amparo a Pesquisa do Estado do Rio deJaneiro (FAPERJ),No.2016/02 (to GRF);Instituto Nacional de Cienciae Tecnologia de Neurociencia Translacional (INNT/INCT),No.465346/2014-6 (to RAMR).

摘　　要：Nervous system emerges from complex signaling interactions where extrinsic (neurotransmitters and trophic factors, among others) and intrinsic factors (transcription factors) interplay in the developing tissue to control gene activity promoting chronic changes in cell genesis, migration, differentiation and death. The retinal microenvironment is regulated by a broad variety of chemicals, including endocannabinoids and nucleotides that modulate embryonic progenitor-neuron-Müller glia signaling in very early developing or pathophysiological conditions.

关 键 词：INTERACTION NUCLEOTIDE SYSTEMS cell death 

分 类 号：R[医药卫生]