武汉地区3219例不孕不育患者细胞遗传学分析  

Cytogenetic analysis of 3 219 infertile patients in Wuhan area

作　　者：段秀娟 石鑫玮[1] 吴媛媛 赵岚[2] 苏斌涛[2] 吴行飞[2] DUAN Xiu-juan;SHI Xin-wei;WU Yuan-yuan;ZHAO Lan;SU Bin-tao;WU Xing-fei(Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei 430030,P. R. China;Department of Clinical Laboratory,Wuhan First Hospital,Wuhan Hubei 430022,P. R. China)

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030 [2]武汉市第一医院检验科,湖北武汉430022

出　　处：《中国计划生育和妇产科》2019年第7期51-54,共4页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的探讨不孕不育患者染色体异常核型、多态性的遗传效应,为其诊断、咨询提供有效指导。方法对2011年7月至2018年7月在华中科技大学同济医学院附属同济医院和武汉市第一医院生殖医学科就诊的3 219例不孕不育患者进行染色体检查并进行细胞遗传学分析。结果 3 219例不孕不育患者中染色体异常核型97例(3.01%),其中染色体数目异常35例(1.09%),均为性染色体异常;染色体结构异常62例(1.93%),以易位居多;染色体多态性127例(3.95%)。结论染色体异常是导致不孕不育的重要因素,染色体多态性改变应引起重视,关注它们在不孕不育中的影响。Objective To discuss the genetic effects of abnormal chromosome karyotype and chromosome polymorphism in infertile patients and provide effective guidance for their diagnosis and counseling. Methods Chromosome examinations were performed on 3 ,219 infertile patients in the Department of Reproductive Medicine in Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology and Wuhan First Hospital from July 2011 to July 2018. Results The abnormal chromosome karyotype rate was 3. 01 %. Among them, there were 35 cases with abnormal sex chromosome number, and the rate of abnormal chromosome structure was 1.93 %, with most of abnormal chromosome structure were translocations. The rate of chromosomal polymorphism was 3. 95 %. Conclusion Chromosomal abnormalities are important factors leading to infertility, and chromosomal polymorphism changes and their effects in infertility should be paid attention to.

关 键 词：不孕不育 染色体核型分析 染色体异常 染色体多态性 

分 类 号：R715.5[医药卫生—妇产科学]