The preparation of Garcinia Glycosides solid dispersion and intestinal absorption by rat in situ single pass intestinal perfusion  

作　　者：Shengnan Li Jingchao Ji Yinghui Chen Ye Chen Ju Liu Yang Wang Hongsheng Liu 

机构地区：[1]Research Center for Computer Simulating and Information Processing of Biomacromolecules of Liaoning Province,School of Pharmacy, Liaoning University, Shenyang City, Liaoning Province, 110036, China [2]School of Life Sciences, Liaoning University, Shenyang City, Liaoning Province, 110036, China

出　　处：《Journal of Pharmaceutical and Biopharmaceutical Research》2019年第1期15-20,共6页制药与生物制药研究杂志（英文）

摘　　要：Garcinia Glycosides is a candidate drug obtained by structural modification of Gambogic Acid (GA), which was acquired through High Throughput Screening(HTS). As Garcinia Glycosides is an effective but insoluble anti-tumor drug, the aim of this study was to obtain a solid dispersion form Garcinia Glycosides by using solvent-melt method so that improve the solubility and dissolution rate. The solid dispersion was characterized by High Performance Liquid Chromatography (HPLC), infrared spectroscopy and evaluated the intestinal absorption of the drug by rat in situ single pass intestinal perfusion. The results showed the increase of solubility, dissolution velocity and absorption compared to other forms. This indicated that solid dispersion could greatly improve the relative bioavailability of Garcinia Glycosides in vivo.

关 键 词：GARCINIA GLYCOSIDES solid dispersion INTESTINAL PERFUSION in SITU single-pass PERFUSION method 

分 类 号：R[医药卫生]