非典型性脑膜瘤的研究现状  

Research status of atypical meningiomas

作　　者：胡士伟 魏栋[1] 陈功[1] 徐笑 缪宗 季晶[1] 胡卫星[1] HU Shi-wei;WEI Dong;CHEN Gong(Department of Neurosurgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院神经外科

出　　处：《临床神经外科杂志》2019年第4期358-361,共4页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金面上项目[81471269(BA14)];江苏省科技厅自然科学基金[BK20160047(DA16)]

摘　　要：脑膜瘤起源于脊髓和大脑的脑膜覆盖层,是由附着在硬脑膜内层的蛛网膜帽细胞引起的,占成人原发性脑肿瘤的25%~33%。非典型性脑膜瘤这个概念于1993年提出,认为不典型的病变是那些在良性和恶性之间呈现中等程度的病变。非典型脑膜瘤具有复发率高、预后差的特点,且具有独特的临床特征及生物学特性。所以本文就近几年国内外对非典型性脑膜瘤在流行病学、临床表现、术前影像特点、病理学、分子生物学、基因改变及治疗等方面的研究现状进行综述。Meningiomas originate in the meningeal covering of the spinal cord and brain and are caused by arachnoid cap cells attached to the dural inner layer,accounting for 25%-33% of adult primary brain tumors.The concept of atypical meningioma(AM) was proposed in 1993.It is believed that atypical lesions are those with moderate degree between benign and malignant lesions.AM has the characteristics of high recurrence rate and poor prognosis,and have unique clinical and biological characteristics.Therefore,this article reviews the research of AM in epidemiology,clinical manifestations,preoperative imaging features,pathology,molecular biology,gene changes and treatment in recent years.

关 键 词：非典型脑膜瘤 磁共振成像 生物学 遗传学 

分 类 号：R739.45[医药卫生—肿瘤]