Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas  

作　　者：SONG Xin-Jian WANG Xu-Mei SUN Qi HUANG Sheng-Tian WANG Yan 宋新建;王旭梅;孙琦;黄生田;王艳(College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong 643000, China;School of Chemical and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, China)

机构地区：[1]College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong 643000, China [2]School of Chemical and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, China

出　　处：《Chinese Journal of Structural Chemistry》2019年第7期1086-1092,共7页结构化学（英文）

基　　金：supported by the National Natural Science Foundation of China(No.21262012);the Natural Science Foundation of Hubei Province(No.2016CFB400)

摘　　要：N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas 4 a～4 i were designed and synthesized as antitumor agents, and their structures were characterized by IR, 1 H NMR, 13 C NMR,MS and elemental analysis. The single crystal of compound 4 a, C17 H13 FN4 OS, was also determined by X-ray crystallography. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b= 8.7100(15), c = 36.604(6) ?, β = 93.320(3)°, V = 1572.4(5) ?3, Z = 4, F(000) = 704, Dc = 1.438 g/cm3, μ = 0.228 mm-1, R = 0.0600 and wR = 0.1448 for 2743 independent reflections(Rint =0.0418) and 2174 observed ones(I > 2σ(I)). The in vitro antitumor activities of compounds 4 a～4 i were preliminarily evaluated by the standard MTT assay.

关 键 词：1 3 4-THIADIAZOLE UREA crystal structure ANTITUMOR activity 

分 类 号：TQ[化学工程]