急性胰腺炎诊断中血清淀粉酶、脂肪酶与C反应蛋白联合检验的价值  

The Value of Combined Test of Serum Amylase, Lipase and C-reactive Protein in the Diagnosis of Acute Pancreatitis

作　　者：陶慧[1] TAO Hui(Department of Clinical Laboratory,Third People's Hospital of Yancheng,Yancheng,JiangsuProvince,224001 China)

机构地区：[1]江苏省盐城市第三人民医院检验科

出　　处：《中外医疗》2019年第19期180-182,共3页China & Foreign Medical Treatment

摘　　要：目的探究血清淀粉酶、脂肪酶与C反应蛋白联合检验诊断急性胰腺炎效果。方法方便选取2017年1月—2018年8月期间在该院治疗急性重症胰腺炎(实验组)与急性轻型胰腺炎者(观察组)各50例,同时纳入健康者50例(对照组),给予所有受检者行血清淀粉酶、脂肪酶与C反应蛋白、联合检查,观察所有受检者血清淀粉酶、脂肪酶与C反应蛋白指标、不同检验灵敏度与特异度、阴性、阴性预测值。结果实验组血清淀粉酶、脂肪酶、C反应蛋白依次高于观察组、对照组(768.62±19.52)U/L>(592.88±21.69)U/L>(39.52±5.33)U/L;(872.62±27.62)U/L>(691.55±26.82)U/L>(97.52±8.66)U/L;(39.58±5.31)mg/L>(27.82±3.22)mg/L>(2.20±1.06)mg/L;血清淀粉酶+脂肪酶+C反应蛋白检验特异度、灵敏度均高于单一检验法;血清淀粉酶+脂肪酶+C反应蛋白检验阴性预测值、阳性预测值、准确率均明显大于单一检验法,组间差异有统计学意义(P<0.05);血清淀粉酶与脂肪酶、C反应蛋白灵敏度、灵阴性预测值、阳性预测值、准确率、特异度相比差异无统计学意义(P>0.05)。结论急性重型胰腺炎患者血清淀粉酶、脂肪酶与C反应蛋白水平明显大于健康者与急性轻型胰腺炎患者,采用血清淀粉酶、脂肪酶与C反应蛋白联合检验可为临床诊治人员提供评估疾病、预测疾病进展的依据,值得临床进一步大力推广应用。Objective To investigate the effect of serum amylase,lipase and C-reactive protein in the diagnosis of acute pancreatitis.Methods Convenient select from January 2017 to August 2018,50 patients with acute severe pancreatitis(experimental group)and acute mild pancreatitis(observation group)were enrolled in our hospital,and 50 healthy subjects(control group)were enrolled.All subjects were tested for serum amylase,lipase and Creactive protein,and all subjects were observed for serum amylase,lipase and C-reactive protein,different test sensitivity and specificity,negative and negative predictive values.Results Serum amylase,lipase and C-reactive protein in the experimental group were higher than the observation group and the control group(768.62±19.52)U/L>(592.88±21.69)U/L>(39.52±5.33)U/L;(872.62±27.62)U/L>(691.55±26.82)U/L>(97.52±8.66)U/L;(39.58±5.31)mg/L>(27.82±3.22)mg/L>(2.20±1.06)mg/L;serum amylase+lipase+C-reactive protein assay specificity and sensitivity were higher than single test method;serum amylase+lipase+C-reactive protein test negative predictive value,positive predictive value and accuracy were significantly greater than single test method,the difference between groups was(P<0.05);serum amylase and lipase,C-reactive protein sensitivity,negativenegative predictive value,positive predictive value,accuracy,specificity had no significant difference(P>0.05).Conclusion The serum amylase,lipase and C-reactive protein levels in patients with acute severe pancreatitis are significantly higher than those in healthy and acute pancreatitis patients.The combination of serum amylase,lipase and Creactive protein can provide clinical diagnosis and treatment for patients with disease assessment.The basis for predicting disease progression is worthy of further clinical application.

关 键 词：脂肪酶 C反应蛋白 急性胰腺炎 血清淀粉酶 联合检验 

分 类 号：R576[医药卫生—消化系统]