Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis  

作　　者：LI Yu-Ze SONG Bei ZHENG Xu-Dong HUANG Wen-Li ZHANG Hua-Wei JIANG Yi YUE Zheng-Gang SONG Xiao-Mei LIU Jian-Li 

机构地区：[1]Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China [2]Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China

出　　处：《Chinese Journal of Natural Medicines》2019年第8期624-630,共7页中国天然药物（英文版）

基　　金：supported by the Open Research Fund of Key Laboratory of Basic and New Herbal Medicament Research,Shaanxi university of Chinese medicine(Nos.17JS030 and 2017KF02);Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019-YL12);the Special Project of Shaanxi Province Education Department(No.14JF005);the National Natural Sciences Foundation of China(No.81503237);the Key R&D Program of Shaanxi Province(Nos.2018SF-324,2017SF-360 and 2015SF073)

摘　　要：Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis,and their structures were determined as tupistrosides J–N(1–5),together with four known furostanol saponins(6–9),on the basis of physico-chemical properties and spectral analysis.Among them,compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5±2.4 and 77.3±2.5μmol·L^–1,respectively.Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6±2.1μmol·L^–1.Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis,and their structures were determined as tupistrosides J–N（1–5）,together with four known furostanol saponins（6–9）,on the basis of physico-chemical properties and spectral analysis.Among them,compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5±2.4 and 77.3±2.5μmol·L–1,respectively.Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6±2.1μmol·L–1.

关 键 词：Tupistra CHINENSIS LILIACEAE Furostanol SAPONINS CYTOTOXICITY 

分 类 号：R284.1[医药卫生—中药学] R965[医药卫生—中医学]