Aetiology of bipolar disorder: contribution of the L-type voltage-gated calcium channels  

作　　者：Xiaoyun Guo Dengtang Liu Tong Wang Xingguang Luo 

机构地区：[1]Department of psychiatry, Shanghai Mental Health Center, Shanghai, China [2]Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA [3]Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA

出　　处：《General Psychiatry》2019年第3期152-154,共3页综合精神医学（英文）

基　　金：National Natural Science Foundation of China (81201057);Shanghai Municipal Health Bureau Project (20124109);Chinese Medical Association, Psychiatry-Servier Youth Research Fund, Shanghai Mental Health Center International Cooperation Project (2013-);Sha叩hai Municipal Center for Mental Health Clinical Research Program.

摘　　要：LTCCS ARE IMPLICATED IN THE PATHOLOGY OF BIPOLAR DISORDER Bipolar disorder (BPD) is a common mental illness with significant morbidity and mortality.1 Although evidence have suggested changes in oxidative stress, dopamine and inflammation in BPD, it is hard to define the aetiological mechanism of BPD clearly. Recently, some but not all candidate gene association studies, family-based association studies, linkage studies, genome-wide association studies (GWASs) and meta-analyses showed that mutation of L-type voltage-gated calcium chan? nels (LTCCs) gene CACNAlCis implicated in the mechanism of BPD.'-8 These findings support the possibility that BPD might have calcium channelopathy.

关 键 词：AETIOLOGY of BIPOLAR DISORDER CONTRIBUTION CALCIUM channels 

分 类 号：R[医药卫生]