Glucagon-like peptide-1 receptor gene polymorphism is associated with fat mass in Chinese nuclear families with male offspring  

作　　者：Shoukui Xiang Luyue Qi Fei Zhao Wenjie Wang Xiaoya Zhang Yunqiu Hu Fei Hua Zhenlin Zhang 

机构地区：[1]Department of Endocrinology,The Third Affiliated Hospital of Soochow University,Changzhou 213003,China [2]Metabolic Bone Disease and Genetic Research Unit,Department of Osteoporosis and Bone Diseases,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China [3]Department of Endocrinology and Metabolism,The Second Affiliated Hospital of Soochow University,Suzhou 215004,China

出　　处：《Acta Biochimica et Biophysica Sinica》2019年第5期545-547,共3页生物化学与生物物理学报（英文版）

基　　金：The work was supported by the grants from the National Natural Science Foundation of China(Nos.81170803,81370978,and 81400852);the National Basic Research Program of China(No.2014CB942903).

摘　　要：Obesity is a serious and growing worldwide health threat associated with increased risk of Type 2 diabetes,hypertension,dyslipidemia,cardiovascular disease,and several forms of cancers[1].It is a complex disease under strong genetic control,and a number of genetic variants for obesity have been identified[2].However,the identified loci explain only a small proportion of the heritability for obesity,suggesting that more associated variants remain to be discovered.Glucagon-like peptide-1(GLP-1)is a potent glucose-dependent insulinotropic gut hormone that is secreted from enteroendocrine L cells of the terminal ileum.In addition to its insulinotropic effects,GLP-1 prevents fat accumulation through various mechanisms[3].GLP-1 exerts its action through the GLP-1 receptor(GLP-1R)which has a wide tissue distribution including adipose tissue.Previous studies have shown that single-nucleotide polymorphisms(SNPs)in the GLP-1R gene may alter binding affinity for GLP-1 and intracellular signaling after hormone-receptor binding[4,5].

关 键 词：Glucagon-like RECEPTOR gene POLYMORPHISM MALE OFFSPRING 

分 类 号：Q[生物学]