茶多酚联合光动力疗法对早期种植体周围炎患者疗效及RANKL、Shh水平的影响  

Effect of tea polyphenols combined with photodynamic therapy on the efficacy and RANKL and Shh levels in patients with early peri-implantitis

作　　者：冯辉[1] 陈一[1] 吕宗凯[1] FENG Hui;CHEN Yi;LYU Zong-kai(Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital,Department of Stomatology,Nanchong, 637000, Sichuan,China)

机构地区：[1]川北医学院第二临床医学院·南充市中心医院口腔科

出　　处：《海南医学院学报》2019年第17期1352-1355,共4页Journal of Hainan Medical University

基　　金：南充市科技局课题(16YFZJ0027)~~

摘　　要：目的:分析茶多酚联合光动力疗法对早期种植体周围炎患者疗效及核因子-κβ受体活化因子配体(receptor activator of nuclear factor kappa-Β ligand,RANKL)、音猬因子(sonic hedgehog,Shh)水平的影响。方法:将我院收治的80例早期种植体周围炎患者随机分为观察组及对照组;对照组采用光动力疗法治疗,观察组采用茶多酚联合光动力疗法治疗;治疗前及治疗3个月后检测患者改良菌斑指数(modified plaque index,mPLI)、种植体周袋深度(peri-implant peripocket depth,PPD)、改良龈沟出血指数(modification sulcus bleedingindex,mSBI)和探诊出血(bleeding on probing,BOP)水平,并检测患者龈沟液中C-反应蛋白(c-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、RANKL及Shh水平。结果:治疗后观察组mPLI、PPD、mSBI及BOP水平明显低于对照组,差异具有统计学意义(P<0.05);治疗后观察组龈沟液中CRP、TNF-α、IL-6、RANKL及Shh水平均明显低于对照组,差异具有统计学意义(P<0.05)。结论:采用茶多酚联合光动力疗法对早期种植体周围炎患者治疗后,可显著提高临床疗效并降低其炎症反应状态,并可有效改善龈沟液中RANKL及Shh水平。Objective: To analyze the effect of tea polyphenols combined with photodynamic therapy on the efficacy and RANKL and Shh levels in patients with early peri-implantitis. Methods: Eighty patients with early peri-implantitis admitted to our hospital from January 2017 to December 2018 were randomly divided into the observation group and the control group;the control group was treated with photodynamic therapy, and the observation group was treated with tea polyphenols combined with photodynamic therapy. The levels of mPLI, PPD, mSBI and BOP were measured before treatment and 3 months after the treatment, and the levels of CRP, TNF-α, IL-6, RANKL and Shh in the gingival crevicular fluid were measured. Results: The levels of mPLI, PPD, mSBI and BOP in the observation group were significantly lower than those in the control group, and the difference was statistically significant ( P <0.05). The levels of CRP, TNF-α, IL-6, RANKL and Shh in the gingival crevicular fluid were observed in the observation group. The differences were significantly lower than the control group, and the difference was statistically significant ( P <0.05). Conclusions: The combination of tea polyphenols and photodynamic therapy for patients with early peri-implantitis can significantly improve clinical efficacy and reduce the inflammatory response, and can effectively improve the levels of RANKL and Shh in gingival crevicular fluid.

关 键 词：茶多酚 光动力疗法 早期种植体周围炎 RANKL SHH 

分 类 号：R783.6[医药卫生—口腔医学]