One-year outcomes of a Neo Hexa sirolimus-eluting coronary stent system with a biodegradable polymer in all-comers coronary artery disease patients: Results from Neo Registry in India  

作　　者：Rajagopal Jambunathan Dinesh Basavanna Preeti Vani Malte Neuss Prashant Janbandhu 

机构地区：[1]Cauvery Heart and Multispecialty Hospital,Mysore,Karnataka 570011,India [2]Department of Cardiology Mysore Medical College and Research Institute,Mysore,Karnataka 570001,India [3]Medical Division,Sahajanand Laser Technology Ltd.,Gandhinagar,Gujarat 382027,India [4]Manemed Research and Development,Roeckumstr,Bonn 53123,Germany

出　　处：《World Journal of Cardiology》2019年第8期200-208,共9页世界心脏病学杂志（英文版）（电子版）

基　　金：Supported by the Sahajanand Laser Technology Ltd,India

摘　　要：BACKGROUND Biodegradable polymer drug-eluting stents(BP-DES)have shown to reduce restenosis rates and have low rates of stent thrombosis.The present postmarketing surveillance assessed 1-year clinical outcomes of patients who had received Neo Hexa DES in real practice.AIM To investigate 1-year clinical outcomes of Neohexa DES in real practice.METHODS Data obtained from a single-center cohort of patients who had received Neo Hexa stents as part of routine treatment of coronary artery disease(CAD)were retrospectively investigated.The primary study endpoint was the rate of major adverse cardiac events(MACEs)defined as the composite of death,myocardial infarction(MI),and target lesion revascularization(TLR)during the follow-up at1 mo,6 mo,and 1 year after the index procedure.RESULTS A total of 129 patients with 172 lesions were enrolled.The most common comorbid conditions were hypertension(49.61%)and diabetes mellitus(39.53%).Procedural success was achieved in all patients,and no in-hospital MACE was reported.The incidence of composite MACE at 30 d,6 mo,and 1 year was 0.78%,3.94%,and 4.87%,respectively.The rate of possible and probable late stent thrombosis was 0.78%.The cumulative incidences of death,MI,and TLR at 1 year were 2.44%,0.81%,and 1.63%,respectively.CONCLUSION The relatively low rates of MACE and stent thrombosis in this study support safety and performance of Neo Hexa stents,suggesting it to be an effective alternative to other contemporary stents for the treatment of de novo lesions in native coronary arteries.BACKGROUND Biodegradable polymer drug-eluting stents(BP-DES) have shown to reduce restenosis rates and have low rates of stent thrombosis. The present postmarketing surveillance assessed 1-year clinical outcomes of patients who had received Neo Hexa DES in real practice.AIM To investigate 1-year clinical outcomes of Neohexa DES in real practice.METHODS Data obtained from a single-center cohort of patients who had received Neo Hexa stents as part of routine treatment of coronary artery disease(CAD) were retrospectively investigated. The primary study endpoint was the rate of major adverse cardiac events(MACEs) defined as the composite of death, myocardial infarction(MI), and target lesion revascularization(TLR) during the follow-up at1 mo, 6 mo, and 1 year after the index procedure.RESULTS A total of 129 patients with 172 lesions were enrolled. The most common comorbid conditions were hypertension(49.61%) and diabetes mellitus(39.53%).Procedural success was achieved in all patients, and no in-hospital MACE was reported. The incidence of composite MACE at 30 d, 6 mo, and 1 year was 0.78%,3.94%, and 4.87%, respectively. The rate of possible and probable late stent thrombosis was 0.78%. The cumulative incidences of death, MI, and TLR at 1 year were 2.44%, 0.81%, and 1.63%, respectively.CONCLUSION The relatively low rates of MACE and stent thrombosis in this study support safety and performance of Neo Hexa stents, suggesting it to be an effective alternative to other contemporary stents for the treatment of de novo lesions in native coronary arteries.

关 键 词：SIROLIMUS DRUG-ELUTING stent Myocardial infarction THROMBOSIS Coronary artery disease 

分 类 号：R[医药卫生]