Hepatocellular carcinoma successfully treated with ALPPS and apatinib: A case report  

作　　者：Ling Liu Nian-Feng Li Qi Zhang Ling Lin 

机构地区：[1]Department of Hepatobiliary and Pancreatic Surgery,Xiangya Hospital, Central South University

出　　处：《World Journal of Clinical Cases》2019年第16期2384-2392,共9页世界临床病例杂志

摘　　要：BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has becoming ever more recognized in the treatment of hepatocellular carcinoma (HCC).Nevertheless,long-term survival rate and postoperative complications are far from ideal,mainly since the majority of patients treated with ALPPS surgery have large or multiple lesions and microvascular tumor thrombus.CASE SUMMARY We present the case of a 47-year-old male patient with a huge right hepatic mass and an estimated insufficient residual liver,who was successfully treated with ALPPS surgery and apatinib.Postoperative pathology revealed HCC with several significant microvascular embolisms.Twenty months after operation,no tumor reoccurrence was observed.CONCLUSION Our case indicated that combined targeted drug therapy with ALPPS can lead to long-term survival for patients with large HCC.BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) has becoming ever more recognized in the treatment of hepatocellular carcinoma(HCC). Nevertheless, long-term survival rate and postoperative complications are far from ideal, mainly since the majority of patients treated with ALPPS surgery have large or multiple lesions and microvascular tumor thrombus.CASE SUMMARY We present the case of a 47-year-old male patient with a huge right hepatic mass and an estimated insufficient residual liver, who was successfully treated with ALPPS surgery and apatinib. Postoperative pathology revealed HCC with several significant microvascular embolisms. Twenty months after operation, no tumor reoccurrence was observed.CONCLUSION Our case indicated that combined targeted drug therapy with ALPPS can lead to long-term survival for patients with large HCC.

关 键 词：HEPATOCELLULAR carcinoma Associating liver PARTITION and PORTAL VEIN LIGATION for staged HEPATECTOMY Apatinib Case report 

分 类 号：R[医药卫生]