唐氏综合征中孕期血清学筛查中MOM值稳定性的探讨  

Discussion on the stability of MOM valuesin pregnancy serological screening in Down’s syndrome

作　　者：于璐[1] 吕巍[1] YU Lu;LV Wei(Beijing Maternity Hospital Affiliated to Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100026)

机构地区：[1]首都医科大学附属北京妇产医院北京妇幼保健院

出　　处：《中国优生与遗传杂志》2019年第8期946-948,F0003,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨唐氏综合征中孕期血清学筛查中,易造成检测值不稳定的因素。方法回顾性分析北京妇产医院2014年至2017年间,127 079例唐氏综合征中孕期血清学检测结果,观察区域性中位数建立后MOM值的稳定性;分析不同月份中,AFP、freeβ-hCG、uE3的MOM值的变化有无显著差异,以及可能引起检测数据波动的因素。结果区域性中位数建立后,AFP、freeβ-hCG的检测MOM值稳定(0.9<MOM<1.1),在不同月份中无明显差异(P<0.05);uE3检测MOM值在不同月份中有显著差异(P<0.01),且与湿度值显著相关(P<0.01)。Objective:To explore the factors that may easily cause unstable test values in the serological screening of pregnancy in Down’s syndrome. Methods:From 2014 to 2017,the serological test results of 127079 cases of down’s syndrome in pregnancy were retrospectively analyzed,and the stability of MOM values after the establishment of regional median was observed. Whether there were significant differences in the MOM values of AFP,freeβ-HCG and uE3 in different months,as well as the factors that may cause the fluctuation of the detection data. Results:After the regional median was established,the measured MOM values of AFP and freeβ-HCG were stable,and there was no significant difference in different months(P<0.05). The detected MOM values of uE3 were significantly different in different months(P<0.01),and were significantly correlated with humidity values(P<0.01).

关 键 词：血清学产前筛查 甲胎蛋白 游离人绒毛促性腺激素 游离雌三醇 MOM值 阳性率 

分 类 号：R576.1[医药卫生—消化系统]