Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine  

作　　者：FU Dongjie DUAN Haiying 付东杰;LU Yi;GAO Shaohuai;PENG Youjian;段海英(Department of Stomatology,Renmin Hospital of Wuhan University,Wuhan 430060,China;The State Key Laboratory Breding Base of Basic Science of Stomatology(Hubei-MOST),Wuhan 430079,China;Wuhan Centural Chinese Construction Third Engineering Bureau, Wuhan 430022,China)

机构地区：[1]Department of Stomatology,Renmin Hospital of Wuhan University,Wuhan 430060,China [2]The State Key Laboratory Breding Base of Basic Science of Stomatology(Hubei-MOST),Wuhan 430079,China [3]Wuhan Centural Chinese Construction Third Engineering Bureau, Wuhan 430022,China

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2019年第4期968-972,共5页武汉理工大学学报（材料科学英文版）

摘　　要：In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine(DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates. The prepared MET-decorated Ti interfaces were prepared for surface characterization tests:contacting angle measurements, scanning electron microscope, ATR-FTIR spectroscopy and in vitro anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confirmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good in vitro antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes.In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine(DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates. The prepared MET-decorated Ti interfaces were prepared for surface characterization tests:contacting angle measurements, scanning electron microscope, ATR-FTIR spectroscopy and in vitro anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confirmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good in vitro antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes.

关 键 词：DOPAMINE metronidazole-decorated ANTIBACTERIAL ACTIVITY 

分 类 号：TB[一般工业技术]