Clinical and dermoscopic features of surgically treated melanocytic nevi: a retrospective study of 1046 cases  

作　　者：Qian-Xi Li David L Swanson Ping Tu Shu-Xia Yang Hang Li 

机构地区：[1]Department of Dermatology and Venerology, Peking University First Hospital, Beijing 100034, China [2]Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing 100034, China [3]National Clinical Research Center for Skin and Immune Diseases, Beijing 100034, China [4]Department of Dermatology, Mayo Clinic, Scottsdale, AZ 85259, USA

出　　处：《Chinese Medical Journal》2019年第17期2027-2032,共6页中华医学杂志（英文版）

基　　金：The work was supported by grants from Clinical Characteristics and Application Research of Capital, Beijing Municipal Science and Technology Commission (No. Z121107001012162);the National Natural Science Foundation of China (No. 81572675).

摘　　要：Background: Compared with Caucasians, unique demographic and clinical features have been reported in Chinese patients with malignant melanoma, but similar comparative studies of melanocytic nevi (MN) are lacking. This study examined the clinical and dermoscopic features of MN in surgically treated Chinese cases. Methods: Clinical data and dermoscopic findings from 1046 cases of MN were collected and analyzed. Cases were treated from January 1 to December 31, 2014 at the Department of Dermatology and Venerology, Peking University First Hospital. The association between nevi location and histologic subtypes was examined with Chi-squared test and univariate logistic regression. Chi-squared test was also used to analyze the proportion of globular patterns across different body sites, and proportion of parallel furrow patterns across different histologic subtypes. Results: The majority of the nevi were from female patients, irrespective of location. The range of age at the time of nevi onset was from 0 (birth) to 79 years. There were 381 (36.4%, 381/1046) congenital nevi;of these 81.6%(311/381) were present at birth. Nevi appeared before 30 years of age in 83.2%(870/1046) of the cases. Median values of length growth rate in congenital and acquired MN were 2.0 and 1.6, respectively. Median values of length growth rates in four age groups (0–9, 10–19, 20–29, and ≥30 years) of congenital nevi were 2.2, 2.0, 2.4, and 2.0, respectively. In acral nevi, which often need to be differentiated from acral lentiginous melanoma, 50.2%(109/217) were junctional (odds ratio [OR];95% confidence interval [CI]: 91.572 [52.210–160.959], P < 0.05). Acral location was also associated with a higher likelihood of compound nevi subtype (OR [95% CI]: 14.468 [8.981–23.306], P < 0.05). The globular (59.4%, 354/596) and pseudonetwork (48.8%, 291/596) dermoscopic patterns were often seen in the head and neck region. In areas other than head and neck and acral regions, the globular pattern was the commonest pattern (34.8%, 71/204) regar

关 键 词：NEVUS MELANOMA DERMOSCOPY 

分 类 号：R[医药卫生]