Thyroid function of twin-pregnant women in early pregnancy  

作　　者：Yan-Xin Jiang Wei-Jie Sun Yang Zhang Yu Huang You-Yuan Huang Gui-Zhi Lu Jun-Qing Zhang Ying Gao Hui-Xia Yang Xiao-Hui Guo 

机构地区：[1]Department of Endocrinology, Peking University First Hospital, Beijing 100034, China [2]Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China [3]National Engineering Research Center of Software Engineering, Peking University, Beijing 100871, China

出　　处：《Chinese Medical Journal》2019年第17期2033-2038,共6页中华医学杂志（英文版）

摘　　要：Background: Serum human chorionic gonadotrophin (hCG) is higher in twin than that in singleton pregnancies. As hCG stimulates the thyroid to produce more free thyroxine (FT4), which may lead to decreased thyroid-stimulating hormone (TSH) levels, the reference ranges of thyroid-related indicators may differ between singleton and twin pregnancies in the first trimester. This study aimed to establish reference ranges for thyroid-related indicators in early twin pregnancies and to compare them with singleton pregnancies. Methods: Data of 820 twin-pregnant women were extracted from the established database of all pregnant women who delivered at Peking University First Hospital from October 2013 to May 2018;160 who met National Academy of Clinical Biochemistry criteria were included to establish TSH and FT4 reference ranges. We screened 480 (3:1 paired) women with singleton pregnancies from the same database as controls. The Mann-Whitney test for TSH and FT4 levels was applied for comparisons between singleton and twin pregnancies. Results: First-trimester reference ranges (4–12 gestational weeks) for twin pregnancies were: TSH 0.69 (0.01–3.35) mIU/L and FT4 16.38 (12.45–23.34) pmol/L. Median TSH was significantly lower at 7 to 12 gestational weeks than that at 4 to 6 gestational weeks (0.62 vs. 0.96 mIU/L, Z =-1.964, P = 0.049);FT4 was not significantly different between the two groups. Compared to singleton pregnancies, median TSH was significantly lower (0.69 vs. 1.27 mIU/L, Z =-6.538, P = 0.000), and FT4 was significantly higher (16.38 vs. 14.85 pmol/L, Z =-7.399, P = 0.000) in twin pregnancies in the first trimester. Conclusions: Specific reference ranges for thyroid-related indicators for twin pregnancies are needed to avoid a misdiagnosis of thyroid dysfunction. Moreover, establishment of separate reference ranges for 4 to 6 and 7 to 12 gestational weeks in twin pregnancies may be considered.

关 键 词：TWIN PREGNANCY Reference RANGES Thyroid-stimulating HORMONE Free THYROXINE 

分 类 号：R[医药卫生]