甘草苷的合成及抗氧化活性研究  

Synthesis and Antioxidant Activity of Liquiritin

作　　者：张光辉[1] 郭惠[1] 张拴[1] 赵忠孝[1] 闫浩 ZHANG Guanghui;GUO Hui;ZHANG Shuan;ZHAO Zhongxiao;YAN Hao(College of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学药学院

出　　处：《化学与生物工程》2019年第10期16-19,共4页Chemistry & Bioengineering

基　　金：陕西省科技厅项目(2016SF-102);陕西省高校科协青年人才托举计划项目(20170406);陕西中医药大学自然科学培育基金项目(2016PY19)

摘　　要：以间苯二酚、冰醋酸、对烷氧基苯甲醛为原料,经酰化、羟醛缩合、关环反应合成了甘草苷(Ⅲ),通过1HNMR、FTIR、MS对其结构进行了表征,并通过测定其对DPPH自由基的清除率来评价其抗氧化活性。结果表明:甘草苷具有较强的抗氧化活性,当浓度为2.00mg·mL^-1时,甘草素、甘草甲苷(Ⅲa)、甘草乙苷(Ⅲb)对DPPH自由基的平均清除率分别为51.56%、44.85%、34.53%,其抗氧化活性大小为:甘草素>甘草甲苷(Ⅲa)>甘草乙苷(Ⅲb);甘草素的2个酚羟基为其抗氧化活性有效部位。Using resorcinol,glacial acetic acid,and p-alkoxybenzaldehyde as raw materials,we synthesized liquiritin(Ⅲ)by acylation,aldol condensation,and cyclization reactions.Moreover,we characterized their structures by 1HNMR,FTIR,and MS,and evaluated their antioxidant activities through determining the scavenging rate of DPPH free radical.The results indicate that liquiritin has strong antioxidant activity.When the concentration is 2.00 mg·mL^-1,the average scavenging rates of DPPH free radical by liquiritigenin,liquiritinⅢa,and liquiritinⅢb are 51.56%,44.85%,and 34.53%,respectively.The sequence of antioxidant activity is liquiritigenin>liquiritinⅢa>liquiritinⅢb.The two phenolic hydroxyls of liquiritigenin are the effective sites of antioxidant activity.

关 键 词：间苯二酚 对烷氧基苯甲醛 甘草素 甘草苷 合成 抗氧化活性 

分 类 号：R284.2[医药卫生—中药学]