pN0期非小细胞肺癌组织中PDGF-B和PDGFR-α的表达及与淋巴结微转移的关系  

Expression of PDGF-B and PDGFR-α in pN0 non-small cell lung cancer and its relationship with lymph node micrometastasis

作　　者：魏东[1] 薛志芳[1] 刘博[2] 王耀一[3] 郝雁冰[1] Wei Dong;Xue Zhifang;Liu Bo;Wang Yaoyi;Hao Yanbing(Department of Thoracic Surgery,The First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075000,China;Department of Pathology,The First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075000,China;Department of Radiology,The First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院胸外科,河北张家口075000 [2]河北北方学院附属第一医院病理科,河北张家口075000 [3]河北北方学院附属第一医院放射科,河北张家口075000

出　　处：《现代肿瘤医学》2019年第22期3997-4001,共5页Journal of Modern Oncology

基　　金：河北省医学科学研究重点课题(编号:1321047D)

摘　　要：目的:探究pN0期非小细胞肺癌组织中血管源性生长因子B(platelet-derived growth factor B,PDGF-B)和血小板源性生长因子受体α(platelet-derived growth factor receptor-α,PDGFR-α)的表达及与淋巴结微转移的关系。方法:选取河北北方学院附属第一医院2013年1月至2014年12月术后经常规病理检查证实为pN0期的非小细胞肺癌患者106例为研究组,同时选取手术治疗的非肺癌病例48例作为对照组,比较两组PDGF-B和PDGFR-α的表达水平,观察分析不同临床病理参数下及是否伴有微转移患者PDGF-B和PDGFR-α阳性率,并使用此项指标对患者进行微转移诊断,观察其诊断特异度及灵敏度。结果:不同性别、年龄、肿瘤分型、肿瘤直径、组织学分析及是否伴有吸烟史患者PDGF-B和PDGFR-α阳性率无显著差异(P>0.05);对照组PDGF-B和PDGFR-α的表达水平显著低于研究组。研究组II-III期PDGF-B、PDGFR-α阳性率显著高于I期患者,伴有微转移患者PDGF-B和PDGFR-α阳性率显著高于无微转移患者,差异具有统计学意义(P<0.05)。结论:PDGF-B及PDGFR-α的表达对pN0期非小细胞肺癌患者微转移的判定具有重要意义,其过表达可能预示患者伴有微转移,能为术后患者治疗方案的制定提供一定依据。Objective:To investigate the relationship between PDGF-B and PDGFR-α expression and lymph node micrometastasis in pN0 non-small cell lung cancer.Methods:A total of 106 patients with non-small cell lung cancer who were confirmed to have pN0 stage by routine pathological examination from January 2013 to December 2014 in the First Affiliated Hospital of Hebei North University were selected as the study group.48 cases were used as the control group.The expression levels of PDGF-B and PDGFR-α were compared between the two groups.The positive rate of PDGF-B and PDGFR-α in patients with micrometastasis under different clinical pathological parameters was analyzed and used.The patient underwent micrometastasis diagnosis and observed its diagnostic specificity and sensitivity.Results:There were no significant differences in the positive rates of PDGF-B and PDGFR-α between the gender,age,tumor type,tumor diameter,histological analysis and whether there was a history of smoking(P>0.05).The expression levels of PDGF-B and PDGFR-α in the control group were significantly lower than those of the study group.The positive rates of PDGF-B and PDGFR-α in stage II-III were significantly higher than those in stage I,and the positive rates of PDGF-B and PDGFR-α were significantly higher in patients with micrometastasis.For patients without micrometastasis,the difference was statistically significant(P<0.05).Conclusion:The expression of PDGF-B and PDGFR-α is important for the determination of micrometastasis in patients with pN0 non-small cell lung cancer.Overexpression may indicate that patients with micrometastasis may provide a basis for the development of treatment options for postoperative patients.

关 键 词：pN0期 非小细胞肺癌 PDGF-B PDGFR-Α 淋巴结微转移 

分 类 号：R734.2[医药卫生—肿瘤]