Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin  

作　　者：Yiqiong Liu Yunong Sun Xiaoyan Zhao Ji-Young Kim Lu Luo Qian Wang Xiaolu Meng Yonghui Li Nan Sui Zhou-Feng Chen Chuxiong Pan Liang Li Yan Zhang 

机构地区：[1]State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China [2]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China [3]Department of Anesthesiology, Department of Psychiatry, Department of Developmental Biology, Center for the Study of Itch, Washington University School of Medicine, Saint Louis, MO 63110, USA [4]School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China [5]Beijing Institute for Brain Disorders, Beijing 100069, China [6]Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China [7]Hendrix College, Conway, AR 72032, USA [8]PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China

出　　处：《Neuroscience Bulletin》2019年第5期841-852,共12页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (81425009, 31630028, 91632305, 30950030, 31170988, and 81671044);the National Basic Research Development Program (973 Program) of China (2009CB522002)

摘　　要：Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions.Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions.

关 键 词：5-HT AGGRESSION SOCIAL ISOLATION DOPAMINE Lmx1b 

分 类 号：R[医药卫生]