应用人造口腔模拟挤压装置研究口含烟烟碱释放的影响因素  

Study on key factors behind nicotine release from snus with a buccal cavity simulator

作　　者：田永峰 李鹏[2] 刘泽 孙世豪[2] 董高峰 张杰[3] 王昆淼 段沅杏 汤建国 杨柳 杨继 陈永宽 缪明明 刘志华 TIAN Yongfeng;LI Peng;LIU Ze;SUN Shihao;DONG Gaofeng;ZHANG Jie;WANG Kunmiao;DUAN Yuanxing;TANG Jianguo;YANG Liu;YANG Ji;CHEN Yongkuan;MIAO Mingming;LIU Zhihua(Technology Center,China Tobacco Yunnan Industrial Co.,Ltd.,Kunming 650231,China;Zhengzhou Tobacco Research Institute of CNTC,Zhengzhou 450001,China;Beijing Cigarette Factory,Shanghai Tobacco Group Co.,Ltd.,Beijing 100024,China)

机构地区：[1]云南中烟工业有限责任公司技术中心,昆明市650231 [2]中国烟草总公司郑州烟草研究院,郑州450001 [3]上海烟草集团有限责任公司北京卷烟厂,北京市100024

出　　处：《烟草科技》2019年第10期68-74,共7页Tobacco Science & Technology

基　　金：云南中烟工业有限责任公司科技项目“新型烟草产品开发前沿技术研究及应用”（2017XY01）

摘　　要：为研究含水率、烟粉粒径和pH 对口含烟烟碱释放率的影响,开发了一套模拟口含烟烟碱在口腔中释放的分析系统,并建立了口含烟烟碱体外释放的分析方法。参照Swedish Match GothiaTek■标准制备口含烟样品,考察了不同含水率、烟粉粒径和pH 条件下烟碱的体外溶出规律。结果表明:①含水率30%样品与10%样品相比,2 min 内烟碱释放率提升40%;含水率超过30%时,样品的烟碱释放率变化不明显。②初始2 min 内,烟粉粒径180 μm 样品的烟碱释放率是烟粉粒径1 700 μm 样品的3 倍。③在6.7、7.4 和8.5 三个pH 条件下,样品中的烟碱均可有效释放。④口含烟烟碱释放的3 个影响因素模型符合指数函数,拟合系数R2大于0.95。该研究结果可为口含烟的质量评价、烟碱释放调控提供参考。In order to investigate the effects of moisture content, tobacco powder particle size and pH on the nicotine release rate in snus, an analytical instrument to simulate the nicotine release in buccal cavity was developed with an accompanied method for the in vitro release of nicotine. The snus samples were prepared according to the Swedish Match GothiaTek■ standard. The in vitro release behaviors of nicotine were measured under different moisture contents, tobacco particle sizes and pH values. The results showed that: 1) Comparing with the sample at 10% moisture content, the nicotine release rate at 30% moisture content was raised by 40% within 2 min. When the moisture content was above 30%, nicotine release rate did not change significantly. 2) Within the initial 2 min, the nicotine release rate for samples with 180 μm tobacco particle size was three times that of 1 700 μm. 3) The nicotine in the samples could be effectively released at pH 6.7, 7.4 and 8.5. 4) The 3-factor models of nicotine release for the snus samples followed an exponential function with the fitting coefficient R2 higher than 0.95. The results of this study provide a theoretical and practical reference for the product quality and nicotine release for snus development.

关 键 词：口含烟 口腔模拟装置 烟碱释放 含水率 烟粉粒径 PH 

分 类 号：TS411.1[农业科学—烟草工业]