高纯度萘呋胺酯草酸盐的制备及其某些单晶分子结构  

Preparation of Highly Purified Nafronyl Oxalate and Its X-Ray Single Crystal Structure

作　　者：薛敏[1] 汪进良[1] 余伟发[1] 王道林[1] 章军[1] 周智明[1] 

机构地区：[1]北京理工大学化工与材料学院,北京100081

出　　处：《北京理工大学学报》2002年第5期658-661,共4页Transactions of Beijing Institute of Technology

摘　　要：根据英国药典 (1998版 )萘呋胺酯草酸盐质量标准要求 ,采用柱层析、高真空蒸馏、重结晶等化学及物理手段以及不同工艺相结合的方法 ,降低杂质含量 ,经 HPL C分析表明 :采用高真空蒸馏和水重结晶相结合的方法可使产品质量达到英国药典要求 ,最终得到主产品质量分数高达 99.6 %以上的高纯度萘呋胺酯草酸盐 ;并首次报道了萘呋胺酯草酸盐两个非对映异构体单晶分子结构 .Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99.6% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.

关 键 词：萘呋胺酯草酸盐 HPLC 柱层析 高真空蒸馏 重结晶 非对映异构体 脑血管药物 

分 类 号：R972[医药卫生—药品] TQ463[医药卫生—药学]