精神分裂症与儿茶酚邻位甲基转移酶基因多态性的关联分析  

Association between schizophrenia and catechol-O-methyltransferase gene polymorphism

作　　者：汤宜朗[1] 王玉凤[1] 周儒伦[1] 周朝凤[1] 蔡焯基[2] 

机构地区：[1]北京大学精神卫生研究所 [2]首都医科大学附属北京安定医院

出　　处：《中华精神科杂志》2002年第4期195-197,共3页Chinese Journal of Psychiatry

摘　　要：目的　探讨精神分裂症与儿茶酚邻位甲基转移酶 (COMT)基因Val1 58Met多态性的关系。方法　采用聚合酶链反应技术检测符合诊断标准的 476例精神分裂症患者 (病例组 )和 2 0 7名正常对照者 (对照组 )的COMT基因Val 1 58Met多态性 ,并进行关联分析。结果　 (1 )病例组与对照组基因型及等位基因分布频率的差异无显著性 (P >0 0 5) ;(2 )首次起病以阳性症状为主的患者Val 1 58Val基因型 (56 5 % )高于非阳性症状为主型者 (45 5 % ;P =0 0 7) ;(3)在男性患者中 ,不吸烟患者的Met1 58Met基因型分布频率 (1 1 9% )高于吸烟患者 (4 1 % ;P <0 0 5 ,OR =3 1 37) ;两者等位基因分布的差异无显著性 (P >0 0 5)。Objective To investigate the association between Val158Met polymorphism in the Catechol O methyltransferase gene exon Ⅳ and schizophrenia in Chinese Han population Methods The case control association study was adopted to analyze the association between the Val158Met polymorphism in the Catechol O methyltransferase gene exon Ⅳ and schizophrenia in 476 DSM Ⅳ schizophrenics and 207 psychiatrically normal controls Results (1) In total, there were no significant differences of genotypic and allelic distribution between the schizophrenics and normal controls (2)Among the schizophrenics, the frequency of Val158Val genotype in patients with positive syndrome at the first onset was higher than that with non positive symptomatology (56 5% vs 45 5%, P =0 07) (3)The frequency of Met158Met genotype in non smokers of male patients was significantly higher than in smokers (11 9% vs 4 1%, P <0 05, OR =3 137) Conclusion The findings suggest that the COMT gene polymorphism may be associated with some clinical features of schizophrenia

关 键 词：精神分裂症 儿茶酚邻位甲基转移酶 多态现象 遗传学 COMT 聚合酶链反应技术 

分 类 号：R749.3[医药卫生—神经病学与精神病学]