A practical synthesis of β-carbolines by tetra-n-butylammonium bromide (TBAB)-mediated cycloaromatization reaction of aldehydes with tryptophan derivatives  

作　　者：Zhen Wang Zhenzhen Yu Yao Yao Yakai Zhang Xuefeng Xiao Bin Wang 

机构地区：[1]College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research,Nankai University,Tianjin 300353,China [2]Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China

出　　处：《Chinese Chemical Letters》2019年第8期1541-1544,共4页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China (Nos. 21172120 and 21472093);Tianjin Municipal Science and Technology Commission (No. 14JCYBJC20600) for financial support

摘　　要：A mild and efficient n Bu4 NBr-mediated oxidative cycloaromatization to prepareβ-carbolines from readily available tryptophans and aldehydes is described.The reaction is practical and allows the synthesis ofβ-carbolines on gram-scale.Some of products crystallized from the reaction mixture and were easily removed by filtration,obviating the need for chromatographic separation.A mild and efficient n Bu4 NBr-mediated oxidative cycloaromatization to prepare β-carbolines from readily available tryptophans and aldehydes is described. The reaction is practical and allows the synthesis of β-carbolines on gram-scale. Some of products crystallized from the reaction mixture and were easily removed by filtration, obviating the need for chromatographic separation.

关 键 词：CARBOLINES TRYPTOPHAN CYCLOAROMATIZATION TBAB Tetra-n-butylammonium bromide 

分 类 号：O62[理学—有机化学]