Success rates of in vitro fertilization versus intracytoplasmic sperm injection in men with serum anti-sperm antibodies:a consecutive cohort study  

作　　者：Shao-Ming Lu Xiao Li Shi-Li Wang Xiao-Li Yang Yan-Zhen Xu Ling-Ling Huang Jiao-Long Liu Fei-Fei Cai Zi-Jiang Chen 

机构地区：[1]Center for Reproductive Medicine,Shandong Provincial Hospital Affiliated to Shandong University,National Research Center for Assisted Reproductive Technology and Reproductive Genetics,The Key laboratory for Reproductive Endocrinology of Ministry of Education,Jinan 250000,China [2]Maternal and Child Health Care Hospital,Rizhao 276800,China [3]The Medical Scientific Research Center of Guangxi Medical University,Nanning 53000,China [4]Department of Obstetrics,The First Affiliated Hospital of Guangxi Medical University,Nanning 53000,China

出　　处：《Asian Journal of Andrology》2019年第5期473-477,共5页亚洲男性学杂志（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.81471498 and 81760272);the Shandong Scientific Research and Technology Development project(No.2014GSF118129);the Guangxi Natural Science Foundation(No.2016GXNSFDA380010);the Guangxi Scientific Research and Technology Development project(No.Guikegong 1355005-5-7).

摘　　要：Antisperm antibodies(ASAs)are assumed to be a possible causative factor for male infertility,with ASAs detected in 5%-15%of infertile men but in only l%-2%of fertile ones.It remains unclear whether ASAs have an adverse effect on the outcome of in v/tro fertilization(IVF)or intracytoplasmic sperm injection(ICSI).This study investigated differences in the rates of fertilization,pregnancy,and live births associated with serum ASA-positive and ASA-negative men following IVF or ICSI.Five hundred and fifty-four consecutive infertile couples undergoing IVF(n=399)or ICSI(n=155)were included.The two-sample two-sided t-test and Chi-square or Fisher's exact test was used for statistical analysis.Lower rates of fertilization(41.7%vs 54.8%,P=0.03),good embryos(18.9%vs 35.2%,P=0.00),pregnancy(38.5%vs 59.4%,P=0.00),and live births(25.8%vs 42.5%,P=0.00)were observed in men of the IVF group with a positive serum ASA than in those with a negative ASA.ASA positivity/negativity correlated with pregnancy rates(P=0.021,odds ratio[OR]:0.630,95%confidence interval[Cl]:0.425-0.932)and live birth rates(P=0.010,OR:1.409,95%Cl:1.084-1.831)after controlling for the female serum follicle-stimulating hormone level and the couple's ages at IVF.Women coupled with ASA-positive men had lower live birth rates with IVF than with ICSI(25.8%and 47.4%,respectively;P=0.07).Women coupled with ASA-positive men had lower rates of pregnancy and live births following IVF than those coupled with ASA-negative men but had a similar outcome with ICSI.

关 键 词：INTRACYTOPLASMIC SPERM injection in VITRO fertilization pregnancy outcome SERUM antisperm ANTIBODIES 

分 类 号：R71[医药卫生—妇产科学]