维生素C多重乳状液的制备及其稳定性研究  

Study on the preparation and stability of Vitamin C multiple emulsions

作　　者：兰宏兵 余述燕 黄秋荣 麻怡 梁雯敏 尹志刚 LAN Hongbing;YU Shuyan;HUANG Qiurong;MA Yi;LIANG Wenmin;YIN Zhigang(College of Material and Chemical Engineering,Zhengzhou University of Light Industry,Zhengzhou 450001,China)

机构地区：[1]郑州轻工业大学材料与化学工程学院

出　　处：《轻工学报》2019年第4期43-51,共9页Journal of Light Industry

基　　金：国家自然科学基金项目(21602207);2018年郑州轻工业学院省级大学生创新创业训练计划项目(201810462026);郑州轻工业学院博士科研基金项目(2014BSJJ009)

摘　　要：以液体石蜡为内乳液油相、Tween-80为外水相乳化剂、明胶为高分子增黏剂,采用两步乳化法制备多重乳状液并对维生素C进行包裹,以离心前后多重乳状液相对体积比和放置2周期间维生素C包裹率的变化值为稳定性衡量标准,通过单因素试验考察乳化剂种类和用量、外内相用量比、乳化温度、均质速度和高分子材料用量等因素对多重乳液稳定性的影响,并确定其中具有显著性影响的3个因素.通过正交试验确立了多重乳状液的最佳配方和制备工艺:以Tween-80和P135分别为外内相乳化剂,Tween-80质量分数为2%,外内相用量比1.0,乳化温度45℃,均质转速2000 r/min,明胶用量0.5%.该条件下,制得的多重乳状液相对体积比为0.966 4,性能稳定,对维生素C的包裹率可达98%,具有令人满意的包裹稳定性.Through two-step emulsification method,the multiple emulsions were firstly prepared with paraffin as internal oil phase,Tween-80 as hydrophilic emulsifier and gelatin as thickener,and then were used to encapsulate Vitamin C.The effect of various parameters on the stability of multiple emulsions was investigated by determining the volume changes after centrifugation and the encapsulation changes of Vitamin C during two weeks.These factors included the species and amount of emulsifier,the dosage ratio of two phases,emulsion temperature,homogenization speed and the dosage of polymer,three of which were most influential.The optimal formula and preparation process were obtained through orthogonal experiment,that was,Tween-80 and P135 as foreign and internal emulsifiers,respectively,the mass ratio of Tween-80 was 2%,the dosage of external phase was 1.0,and the emulsification temperature was 45℃,homogeneous speed was 2000 r/min,gelatin dosage was 0.5%.Under this condition,the relative volume ratio of multiple emulsions was 0.966 4,the performance was stable,and the encapsulation rate of Vitamin C could reach 98%,and the multiple emulsions had a satisfactory package stability.

关 键 词：维生素C 多重乳状液 稳定性 包裹率 

分 类 号：TQ658[化学工程—精细化工] TS974.1[轻工技术与工程]