Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis  

GSTT1纯合子缺失与胰腺癌风险关系的Meta分析（英文）

作　　者：崔君鹏 林美艺 刘正昊 刘宝林 

机构地区：[1]中国医科大学附属盛京医院普外科第六科 [2]中国医科大学附属第一医院风湿科

出　　处：《Chinese Medical Sciences Journal》2019年第3期205-210,共6页中国医学科学杂志（英文版）

摘　　要：Objective To clarify the possible association of GSTT1 homozygous deletion with the susceptibility to pancreatic cancer.Methods We searched PubMed database,Chinese Journal Full Text Database(CNKI),and EMBASE to find the eligible studies published up to April 18,2018 for evaluating the relationship between GSTT1 homozygous deletion and pancreatic cancer.The frequency of null genotype for GSTT1 between the pancreatic cancer group and the healthy control group was compared with Chi-square test,and odds ratios(ORs)value and 95%confidence interval(95%CI)were calculated.Results A total of 9 studies met the inclusion criteria,and 5952 cases consisting of 2387 pancreatic cancer patients and 3565 healthy controls were included in the meta analysis.Compared with the control group,frequency of null genotype for GSTT1 in the pancreatic cancer group was higher(33.4%vs.38.7%,OR=1.26,95%CI=1.01-1.58,P=0.04).Conclusion GSTT1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer.Objective To clarify the possible association of GSTT1 homozygous deletion with the susceptibility to pancreatic cancer.Methods We searched PubMed database, Chinese Journal Full Text Database(CNKI), and EMBASE to find the eligible studies published up to April 18, 2018 for evaluating the relationship between GSTT1 homozygous deletion and pancreatic cancer. The frequency of null genotype for GSTT1 between the pancreatic cancer group and the healthy control group was compared with Chi-square test, and odds ratios(ORs) value and 95% confidence interval(95% CI) were calculated.Results A total of 9 studies met the inclusion criteria, and 5952 cases consisting of 2387 pancreatic cancer patients and 3565 healthy controls were included in the meta analysis. Compared with the control group, frequency of null genotype for GSTT1 in the pancreatic cancer group was higher(33.4% vs. 38.7%, OR = 1.26, 95%CI = 1.01-1.58, P = 0.04).Conclusion GSTT1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer.

关 键 词：PANCREATIC cancer gene GSTT1 SUSCEPTIBILITY META analysis 

分 类 号：R73[医药卫生—肿瘤]