Hypereosinophilia, mastectomy, and nephrotic syndrome in a male patient: A case report  

作　　者：Jian Wu Peng Li Yu Chen Xiang-Hong Yang Meng-Yun Lei Li Zhao 

机构地区：[1]Department of Anesthesiology,Shengjing Hospital,China Medical University,Shenyang 110004,Liaoning Province,China [2]Department of Respiratory Medicine,Shengjing Hospital,China Medical University,Shenyang 110004,Liaoning Province,China [3]Department of Pathology,Shengjing Hospital,China Medical University,Shenyang 110004,Liaoning Province,China [4]Department of Endocriology,Shengjing Hospital,China Medical University,Shenyang 110004,Liaoning Province,China

出　　处：《World Journal of Clinical Cases》2019年第19期3145-3152,共8页世界临床病例杂志

摘　　要：BACKGROUND Hypereosinophilia(HE)is a heterogeneous disease of unknown etiology in which tissue and organ injury is inflicted by excess numbers of circulating or infiltrating eosinophils.Herein,we describe a patient with rare organ damage due to HE and review the pertinent literature.CASE SUMMARY A 43 year-old Chinese man with a 13-year history of eosinophilia and shortness of breath for 7 d presented to our hospital.During the course of his illness,the patient variably presented with gastrointestinal symptoms,eczema,vitiligo,mastitis,joint symptoms,nephrotic syndrome,and interstitial pneumonia.The chronic mastitis proved burdensome,necessitating bilateral mastectomy.HE was diagnosed by repeat bone marrow biopsy,and a kidney biopsy showed focal segmental glomerulosclerosis.Intermittent steroidal therapy is typically initiated to relieve such symptoms,although relapse and organ involvement often ensue once treatment is withdrawn.We administered methylprednisolone sodium succinate(40 mg/d)intravenously for 3 d,followed by oral tablets at the same dose.Subsequent computed tomography(CT)of the chest CT showed relative improvement of the interstitial pneumonia.The patient is currently on a continuous regimen of oral steroid,and his condition is stable.CONCLUSION HE is heterogeneous condition.This is the first reported case of bilateral mastectomy in a male patient with longstanding HE.BACKGROUND Hypereosinophilia(HE) is a heterogeneous disease of unknown etiology in which tissue and organ injury is inflicted by excess numbers of circulating or infiltrating eosinophils. Herein, we describe a patient with rare organ damage due to HE and review the pertinent literature.CASE SUMMARY A 43 year-old Chinese man with a 13-year history of eosinophilia and shortness of breath for 7 d presented to our hospital. During the course of his illness, the patient variably presented with gastrointestinal symptoms, eczema, vitiligo,mastitis, joint symptoms, nephrotic syndrome, and interstitial pneumonia. The chronic mastitis proved burdensome, necessitating bilateral mastectomy. HE was diagnosed by repeat bone marrow biopsy, and a kidney biopsy showed focal segmental glomerulosclerosis. Intermittent steroidal therapy is typically initiated to relieve such symptoms, although relapse and organ involvement often ensue once treatment is withdrawn. We administered methylprednisolone sodium succinate(40 mg/d) intravenously for 3 d, followed by oral tablets at the same dose. Subsequent computed tomography(CT) of the chest CT showed relative improvement of the interstitial pneumonia. The patient is currently on a continuous regimen of oral steroid, and his condition is stable.CONCLUSION HE is heterogeneous condition. This is the first reported case of bilateral mastectomy in a male patient with longstanding HE.

关 键 词：HYPEREOSINOPHILIA MASTECTOMY Nephrotic syndrome INTERSTITIAL PNEUMONIA Case report 

分 类 号：R57[医药卫生—消化系统]