小儿智力糖浆联合阿立哌唑治疗儿童抽动障碍的疗效及其对免疫功能的影响  

Therapeutic Effect of Pediatric Intellectual Syrup Combined with Aripiprazole on Children with Tic Disorder and its Effect on Immune Function

作　　者：孙莹[1] 王惠萍[1] 段丽芬[1] 王春霞[1] 张霞 郑宇霞[1] 王左华 罗超 SUN Ying;WANG Hui-ping;DUAN Li-fen;WANG Chun-xia;ZHANG Xia;ZHENG Yu-xia;WANG Zuo-hua;LUO Chao(Department of Neurology,Children's Hospital of Kunming,Kunming 650034,Yunnan,China)

机构地区：[1]云南省昆明市儿童医院神经内科

出　　处：《医学信息》2019年第20期139-141,共3页Journal of Medical Information

摘　　要：目的探究小儿智力糖浆联合阿立哌唑治疗儿童抽动障碍的临床疗效及其对儿童免疫功能的影响。方法选择我院儿科2017年1月~2018年1月收治的64例抽动障碍患儿作为研究对象,按照随机数字表法分为观察组和对照组,各32例。对照组采用阿立哌唑治疗,观察组在对照组基础上联合小儿智力糖浆治疗,比较两组患儿外周T淋巴细胞亚群及血清免疫球蛋白(Ig)水平、耶鲁综合抽动严重程度量表评分(YGTSS)、注意力缺陷多动障碍评分量表评分(ADHD)及临床疗效。结果观察组运动抽动、发声抽动、功能受损程度及抽动总分均低于对照组,差异有统计学意义(P<0.05);观察组注意力缺陷、多动冲动及ADHD总分低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为96.87%,高于对照组的75.00%,差异有统计学意义(P<0.05);观察组外周血CD3、CD4、CD4/CD8、IgG及IgA均高于对照组,差异具有统计学意义(P<0.05);两组外周血CD8及IgM比较,差异无统计学意义(P>0.05)。结论小儿智力糖浆联合阿立哌唑可有效改善儿童抽动障碍的临床症状和免疫功能,效果优于单用阿立哌唑,临床疗效确切。Objective To investigate the clinical efficacy of pediatric intellectual syrup combined with aripiprazole in the treatment of children with tic disorder and its effect on children's immune function.Methods 64 children with tic disorder admitted to our hospital from January 2017 to January 2018 were enrolled in the study.According to the random number table,the observation group and the control group were divided into 32 cases.The control group was treated with aripiprazole.The observation group was treated with pediatric intellectual syrup on the basis of the control group.The peripheral fasting blood was taken to detect the peripheral T lymphocyte subsets and serum immunoglobulin(Ig)levels.The Yale Comprehensive Tic Severity Scale Scale(YGTSS),Attention Deficit Hyperactivity Disorder Rating Scale(ADHD)and clinical outcome were compared between two groups.Results The twitching,vocal twitching,functional impairment and twitching scores of the observation group were lower than the control group,the difference was statistically significant(P<0.05).The attention deficit,hyperactivity impulse and total ADHD scores in the observation group were lower than the control group,the difference was statistically significant(P<0.05).The total effective rate of the observation group was 96.87%,which was higher than that of the control group 75.00%,the difference was statistically significant(P<0.05).The peripheral blood CD3,CD4,CD4/CD8,IgG and IgA were higher than the control group,the difference was statistically significant(P<0.05).There was no significant difference in CD8 and IgM between the two groups(P>0.05).Conclusion Infant intelligence syrup combined with aripiprazole can effectively improve the clinical symptoms and immune function of children with tic disorder.The effect is better than aripiprazole alone.The clinical effect is exact.

关 键 词：小儿智力糖浆 阿立哌唑 儿童抽动障碍 免疫功能 

分 类 号：R749.94[医药卫生—神经病学与精神病学]