眼睑黄色瘤巨噬细胞清道夫受体1单核苷酸多态性研究  

Study on single nucleotide polymorphisms of macrophage scavenger receptor 1 gene in xanthelasm a palpebrarum patients

作　　者：李永蓉 王志敏[1] 王慧[1] 杨颖秋[1] 纪风涛[1] Yong-Rong Li;Zhi-Min Wang;Hui Wang;Ying-Qiu Yang;Feng-Tao Ji(Department of Ophthalmology,the Second People s Hospital of Hefei,Hefei 230011,Anhui Province,China)

机构地区：[1]中国安徽省合肥市第二人民医院眼科

出　　处：《国际眼科杂志》2019年第11期1986-1988,共3页International Eye Science

基　　金：安徽省合肥市第二人民医院光华基金项目(No.2017-135-04)~~

摘　　要：目的:探讨眼睑黄色瘤与巨噬细胞清道夫受体1(MSR1)基因单核苷酸多态性(SNP)的相关性。方法:分别抽取20例眼睑黄色瘤患者和20例健康者的空腹外周静脉血,应用Sanger测序方法进行MSR1基因型SNP检测,眼睑黄色瘤患者同时进行血脂、α-脂蛋白水平、颈动脉彩超等检查。结果:眼睑黄色瘤患者和健康人MSR1基因型SNP分布无显著差异,但部分合并颈动脉硬化和高血脂症的患者MSR1外显子区域S2-SNP1、S5-SNP2、S5-SNP4位点发生纯合突变。结论:眼睑黄色瘤与抗动脉粥样硬化受体MSR1基因型SNP具有相关性。AIM:To study the single nucleotide polymorphisms(SNPs)of Macrophage Scavenger Receptor 1(MSR1)gene in xanthelasma palpebrarum patients.METHODS:We drew peripheral venous blood from 20 xanthelasma palpebrarum patients and 20 healthy participants.We detected the SNPs of MSR1 gene with Sanger sequencing,examined serum lipids andα-lipoprotein of the patients,and scanned carotid arteries of the patients with color ultrasound.After that,we kept on observation of the participants.RESULTS:There was no significant difference in the SNPs of MSR1 genotype between xanthelasma palpebrarum patients and healthy participants.However,in some patients with carotid atherosclerosis and hyperlipidemia,there were homozygous mutations at S2-SNP1,S5-SNP2 and S5-SNP4 in the exon region of MSR1 gene,which were related to atherosclerosis.CONCLUSION:Xanthelasma palpebrarum is related to SNPs of MSR1 in atherosclerosis.

关 键 词：眼睑黄色瘤 巨噬细胞清道夫受体1 单核苷酸多态性 突变 动脉硬化 

分 类 号：R73[医药卫生—肿瘤]