Small molecule fluorescent probes of protein vicinal dithiols  

作　　者：Guodong Hu Huiyi Jia Lanning Zhao Dong-Hyung Cho Jianguo Fang 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China [2]School of Life Sciences,Kyungpook National University,Daegu 41566,Republic of Korea

出　　处：《Chinese Chemical Letters》2019年第10期1704-1716,共13页中国化学快报（英文版）

基　　金：financial supports from the National Natural Science Foundation of China (Nos. 21572093 & 21778028);the 111 Project

摘　　要：The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes.Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties.The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes.Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties.

关 键 词：FLUORESCENT PROBE PROTEIN VICINAL DITHIOLS Arsenical PROBE THIOL redox Reaction-based PROBE 

分 类 号：O62[理学—有机化学]