植物源细菌群体感应抑制剂的研究进展  

Research Progress on Bacteria Quorum Sensing Inhibitors of Plant-derived

作　　者：唐甜甜 许杰[2] 吴涛 TANG Tian-tian;XU Jie;WU Tao(Institute of Agro-Products Processing Science and Technolgy,CAAS,Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process,Ministry of Agricultrue,Beijing 100193,China;Department of Bioengineering,Binzhou Vocational College,Binzhou 256603,China;Shandong Provincial Engineering and Technology Research Center for Wild Plant Resources Development and Application of Yellow River Delta,Shandong Provincial Key Laboratory of Eco-Environmental Science for Yellow River Delta,College of Biological and Environmental Engineering,Binzhou University,Binzhou 256600,China)

机构地区：[1]中国农业科学院农产品加工研究所,农业部农产品质量安全收贮运管控重点实验室,北京100193 [2]滨州职业学院生物工程学院,山东滨州256603 [3]滨州学院生物与环境工程学院,山东省黄河三角洲野生植物资源开发利用工程技术研究中心,山东省黄河三角洲生态环境重点实验室,山东滨州256600

出　　处：《食品工业科技》2019年第21期331-336,共6页Science and Technology of Food Industry

基　　金：山东省高等学校科技计划项目(J17KB115);滨州职业学院科研项目(2017YJKT05);滨州学院科研基金项目(2013ZDL04)

摘　　要：细菌耐药性的出现已经成为全球公共卫生关注的问题之一,而传统处理耐药性的方法正逐渐失效,寻找新的作用靶点来开发新型抗菌药物至关重要。研究表明,靶向微生物群体感应(Quorum sensing,QS)是一种较好的替代传统抗生素的方法。从自然界中寻找群体感应系统抑制剂(Quorum sensing inhibitor,QSI),尤其是植物源QSI,被认为是解决微生物致病性和食品腐败的有效方法。本文在现有的理论和研究基础上,对植物源细菌群体感应抑制剂的研究现状进行综述,展望了群体感应抑制剂的研发前景,以期为细菌群体感应在微生物耐药性和开发新型防腐剂中的应用提供参考。The emergence of bacterial resistance has become one of the concerns of global public health,and the traditional methods of dealing with drug resistance are gradually becoming invalid. It is essential to find new targets to develop new antimicrobial drugs. Studies have shown that targeting microbial quorum sensing(QS)seems to be a better alternative method to traditional antibiotics. The search for quorum sensing inhibitor(QSI)from nature,especially the plant-derived QSI,is considered to be an effective method to solve microbial pathogenicity and food spoilage. Based on the existing theories and research,this paper reviews the research status and functions of plant-derived bacterial quorum sensing inhibitors,and look forward to prospect the development of the quorum sensing inhibitors,so as to provide reference for the application of the bacteria quorum sensing inhibitors in microbial resistance and the development of new preservatives.

关 键 词：植物源 抑制剂 细菌群体感应 耐药性 

分 类 号：TS201[轻工技术与工程—食品科学]