神经原纤维缠结优势型痴呆  

Neurofibrillary tangle-predominant dementia

作　　者：胡文政 刘帅[2] 甘景环 李张龙 石志鸿[2] 李延峰[4] 纪勇[2,3] Hu Wenzheng;Liu Shuai;Gan Jinghuan;Li Zhanglong;Shi Zhihong;Li Yanfeng;Ji Yong(Graduate School of Tianiin Medical University,Tianjin 300070,China;Department of Neurology,Tianjin Huanhu Hospital,Tianjin 300350,China;Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Department of Neurology,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]天津医科大学研究生院,300070 [2]天津市环湖医院,300350 [3]北京首都医科大学附属北京天坛医院神经病学中心,北京100070 [4]《中国医学科学院北京协和医院神经内科,北京100730

出　　处：《中华老年医学杂志》2019年第11期1312-1316,共5页Chinese Journal of Geriatrics

基　　金：国家自然科学基金(81571057);天津市科技计划项目(16ZXMJSY00010)。

摘　　要：神经原纤维缠结优势型痴呆(NFTPD)是晚发型痴呆的一种类型,临床主要以记忆障碍为主要表现,其病理特征是在海马区域中存在大量神经原纤维缠结(NFT)而脑中没有或很少有淀粉样蛋白沉积。近年来,原发性年龄相关性tau病变(PART)作为新的病理学术语被提出,是指随着年龄增长,神经原纤维缠结出现在颞叶内侧,但无淀粉样蛋白沉积,而NFTPD是与PART病理进展相关的痴呆。Neurofibrillary tangle-predominant dementia(NFTPD)is one type of late-onset dementia,with memory disorders as the main clinical manifestation.The pathological feature is the presence of a large number of neurofibrillary tangle(NFT)in the hippocampus with no or little amyloid deposition in the brain.In recent years,primary age-related tauopathy(PART)has been proposed as a new pathological term,which means that NFT appears in the medial temporal lobe with aging,but no amyloid deposits,and NFTPD is one type of dementia associated with the progression of PART.

关 键 词：神经原纤维缠结 痴呆 神经变性病 

分 类 号：R74[医药卫生—神经病学与精神病学]