The effects of Gekko sulfated glycopeptide and basic fibroblast growth factor on human fibrosarcoma HT1080 cells  

作　　者：Xiao-Hui Liu Cui-Hong Zhu Xiong-Zhi Wu 

机构地区：[1]Tianjin Medical University Cancer Institute and Hospital,National Clinical Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China.

出　　处：《Precision Medicine Research》2019年第4期109-113,共5页精准医学研究

基　　金：This work was supported by grants from the New Century Excellent Talent(NCET-11-1068);National Science Foundation of China(No.81173376).

摘　　要：Background:Fibrosarcoma is a malignant soft tissue tumor of mesenchymal origin.Gekko sulfated glycopeptide(GSPP),an anticancer drug in traditional Chinese medicine,could inhibited the tumor angiogenesis by targeting basic fibroblast growth factor(bFGF).bFGF promoted the proliferation of fibroblasts.Both fibrosarcoma and fibroblasts derived from fibrous connective tissue.This study investigated whether GSPP has the inhibitory effects on human fibrosarcoma HT1080 cells.Materials and methods:The trypan blue exclusion assay was used to determine cell viability and cell numbers.Cells migration was observed by wound-healing and transwell.Results:From the first day to seventh day,HT1080 cells number of GSPP,bFGF,GSPP combined bFGF groups had not change compared with control.HT1080 cells migration distance and the number of migrating cells of GSPP,bFGF,GSPP combined bFGF groups were not significantly reduced.Conclusions:GSPP did not have inhibitory effects on the proliferation and migration of human fibrosarcoma HT1080 cells.Thus further research should be carried out in order to study the mechanism of GSPP and bFGF acting on the tumor stroma.

关 键 词：FIBROSARCOMA BFGF Gekko SULFATED GLYCOPEPTIDES Proliferation Migration 

分 类 号：R73[医药卫生—肿瘤]